Phenotypes associated with this allele

• Allele Symbol: Cdk6^tm3.1Phin
• Allele Name: targeted mutation 3.1, Philip Hinds
• Allele ID: MGI:5141515
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Cdk6^tm3.1Phin/Cdk6^tm3.1Phin	involves: 129 * C57BL/6 * FVB/N	MGI:5141602

Genotype
MGI:5141602

hm1

• Allelic Composition: Cdk6^tm3.1Phin/Cdk6^tm3.1Phin
• Genetic Background: involves: 129 * C57BL/6 * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

increased T cell apoptosis ( J:174697 )

• mice exhibit a greater proportion of apoptotic cells in the DN2 and DN3 compartment compared with Cdk6^tm1.1Phin homozygotes

enlarged thymus ( J:174697 )

• compared with

increased thymocyte number ( J:174697 )

• 1.5-fold compared with Cdk6^tm1.1Phin homozygotes

increased DN1 thymic pro-T cell number ( J:174697 )

• compared with Cdk6^tm1.1Phin homozygotes

abnormal T cell differentiation ( J:174697 )

• mice exhibit a greater proportion of DN2 and DN3 cells in the S-G2-M phases of the cell cycle compared with Cdk6^tm1.1Phin homozygotes

• mice exhibit a greater proportion of apoptotic cells in the DN2 and DN3 compartment compared with Cdk6^tm1.1Phin homozygotes

increased CD4-positive, alpha-beta T cell number ( J:174697 )

• compared with Cdk6^tm1.1Phin homozygotes

increased hematopoietic stem cell number ( J:174697 )

• in the LSK fraction and absolute number of LSK cells compared with Cdk6^tm1.1Phin homozygotes

abnormal hematopoietic stem cell physiology ( J:174697 )

• mice exhibit a 37% increase in the fraction of cycling LSK cells compared with Cdk6^tm1.1Phin homozygotes

• mice exhibit an increase in LSK cell apoptosis compared with Cdk6^tm1.1Phin homozygotes

immune system

immune system phenotype ( J:174697 )

N • mice exhibit normal numbers of DN2 through DN4 cells

increased T cell apoptosis ( J:174697 )

• mice exhibit a greater proportion of apoptotic cells in the DN2 and DN3 compartment compared with Cdk6^tm1.1Phin homozygotes

enlarged thymus ( J:174697 )

• compared with

increased thymocyte number ( J:174697 )

• 1.5-fold compared with Cdk6^tm1.1Phin homozygotes

increased DN1 thymic pro-T cell number ( J:174697 )

• compared with Cdk6^tm1.1Phin homozygotes

abnormal T cell differentiation ( J:174697 )

• mice exhibit a greater proportion of DN2 and DN3 cells in the S-G2-M phases of the cell cycle compared with Cdk6^tm1.1Phin homozygotes

• mice exhibit a greater proportion of apoptotic cells in the DN2 and DN3 compartment compared with Cdk6^tm1.1Phin homozygotes

increased CD4-positive, alpha-beta T cell number ( J:174697 )

• compared with Cdk6^tm1.1Phin homozygotes

cellular

increased T cell apoptosis ( J:174697 )

• mice exhibit a greater proportion of apoptotic cells in the DN2 and DN3 compartment compared with Cdk6^tm1.1Phin homozygotes

endocrine/exocrine glands

enlarged thymus ( J:174697 )

• compared with

increased thymocyte number ( J:174697 )

• 1.5-fold compared with Cdk6^tm1.1Phin homozygotes

increased DN1 thymic pro-T cell number ( J:174697 )

• compared with Cdk6^tm1.1Phin homozygotes

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 10/29/2024 MGI 6.24