About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tg(H2-K1-Ifnb1)10Seif
transgene insertion 10, Isabelle Seif
MGI:5141611
Summary 2 genotypes


Genotype
MGI:5141627
cx1
Allelic
Composition		 Ifnar1tm1Agt/Ifnar1tm1Agt
Tg(H2-K1-Ifnb1)10Seif/Tg(H2-K1-Ifnb1)10Seif
Genetic
Background		 C3.Cg-Ifnar1tm1Agt Tg(H2-K1-Ifnb1)10Seif
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ifnar1tm1Agt mutation (11 available); any Ifnar1 mutation (60 available)
Tg(H2-K1-Ifnb1)10Seif mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
reproductive system phenotype ( J:174828 )
N
• mice exhibit normal fertility
• male mice exhibit normal sperm parameters




Genotype
MGI:5141626
tg2
Allelic
Composition		 Tg(H2-K1-Ifnb1)10Seif/Tg(H2-K1-Ifnb1)10Seif
Genetic
Background		 C3H/HeOuJ-Tg(H2-K1-Ifnb1)10Seif
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(H2-K1-Ifnb1)10Seif mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
reproductive system phenotype ( J:174828 )
N
• female mice exhibit normal fertility
oligozoospermia ( J:174828 )
• at 6 weeks in the epididymis
• dramatic at 9 weeks
seminiferous tubule degeneration ( J:174828 )
• 30% fewer cells at P45
• 70% fewer cells at P60
early reproductive senescence ( J:174828 )
• at 9 weeks, male mice are infertile
decreased litter size ( J:174828 )
• in male mice
abnormal male reproductive system physiology ( J:174828 )
• at P45, fewer proliferating spermatogonia and primary spermatocytes per seminiferous tubules compared with wild-type mice
male infertility ( J:174828 )
• at 9 weeks
reduced male fertility ( J:174828 )
• at 6 weeks

mortality/aging
early reproductive senescence ( J:174828 )
• at 9 weeks, male mice are infertile

endocrine/exocrine glands
seminiferous tubule degeneration ( J:174828 )
• 30% fewer cells at P45
• 70% fewer cells at P60

cellular
oligozoospermia ( J:174828 )
• at 6 weeks in the epididymis
• dramatic at 9 weeks




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory