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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Mdm4tm1Zmy
targeted mutation 1, Zhi-Min Yuan
MGI:5141749
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Mdm4tm1Zmy/Mdm4tm1Zmy involves: 129 * C57BL/6 MGI:5141751
cx2
 		Mdm4tm1Zmy/Mdm4tm1Zmy
Trp53tm1Tyj/Trp53tm1Tyj 		involves: 129S2/SvPas * C57BL/6 MGI:5141752


Genotype
MGI:5141751
hm1
Allelic
Composition		 Mdm4tm1Zmy/Mdm4tm1Zmy
Genetic
Background		 involves: 129 * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mdm4tm1Zmy mutation (0 available); any Mdm4 mutation (193 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
embryonic lethality during organogenesis, complete penetrance ( J:174359 )
• begin to die around E9.5 and all are dead by E13.5

cellular
decreased cell proliferation ( J:174359 )
• in embryos at E9.5

embryo
abnormal embryonic neuroepithelium morphology ( J:174359 )
• begin to die around E9.5 and all are dead by E13.5
absent somites ( J:174359 )
• abnormal embryos lack somites at E9.5

growth/size/body
decreased embryo size ( J:174359 )

cardiovascular system
abnormal heart development ( J:174359 )
• abnormal embryos lack hearts at E9.5

nervous system
abnormal embryonic neuroepithelium morphology ( J:174359 )
• begin to die around E9.5 and all are dead by E13.5




Genotype
MGI:5141752
cx2
Allelic
Composition		 Mdm4tm1Zmy/Mdm4tm1Zmy
Trp53tm1Tyj/Trp53tm1Tyj
Genetic
Background		 involves: 129S2/SvPas * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mdm4tm1Zmy mutation (0 available); any Mdm4 mutation (193 available)
Trp53tm1Tyj mutation (12 available); any Trp53 mutation (240 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:174359 )
• phenotypes are almost identical to control littermates




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory