All Phenotypes Fos<tm3.1Wag> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Fos^tm3.1Wag
targeted mutation 3.1, Erwin F Wagner
MGI:5142238

Summary

2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Fos^tm3.1Wag/Fos^tm3.1Wag	involves: 129P2/OlaHsd * C57BL/6 * SJL	MGI:5142261
cx2	Egfr^wa2/Egfr⁺ Fos^tm3.1Wag/Fos^tm3.1Wag Tg(KRT5-SOS1)892A6Wag/0	involves: 129P2/OlaHsd * C57BL/6 * CBA * SJL	MGI:5142269

Allelic Composition	Fos^tm3.1Wag/Fos^tm3.1Wag
Genetic Background	involves: 129P2/OlaHsd * C57BL/6 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fos^tm3.1Wag mutation (0 available); any Fos mutation (43 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

decreased interleukin-10 secretion ( J:175064 )

• from LPS-treated bone marrow macrophages

increased tumor necrosis factor secretion ( J:175064 )

• from LPS-treated bone marrow macrophages

increased susceptibility to endotoxin shock ( J:175064 )

• LPS-treated bone marrow macrophages exhibit increased TNF-alpha but decreased IL10 production compared with similarly treated wild-type cells

Allelic Composition	Egfr^wa2/Egfr⁺ Fos^tm3.1Wag/Fos^tm3.1Wag Tg(KRT5-SOS1)892A6Wag/0
Genetic Background	involves: 129P2/OlaHsd * C57BL/6 * CBA * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Egfr^wa2 mutation (3 available); any Egfr mutation (87 available)
Fos^tm3.1Wag mutation (0 available); any Fos mutation (43 available)
Tg(KRT5-SOS1)892A6Wag mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased skin papilloma incidence ( J:175064 )

decreased tumor growth/size ( J:175064 )

• tumor burden is reduced compared to in Tg(KRT5-SOS1)892A6Mka mice

integument

increased skin papilloma incidence ( J:175064 )

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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