About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Fostm4.1Wag
targeted mutation 4.1, Erwin F Wagner
MGI:5142239
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Fostm4.1Wag/Fostm4.1Wag involves: 129P2/OlaHsd * C57BL/6 * SJL MGI:5142262
cx2
 		Egfrwa2/Egfr+
Fostm4.1Wag/Fostm4.1Wag
Tg(KRT5-SOS1)892A6Wag/0 		involves: 129P2/OlaHsd * C57BL/6 * CBA MGI:5142272


Genotype
MGI:5142262
hm1
Allelic
Composition		 Fostm4.1Wag/Fostm4.1Wag
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fostm4.1Wag mutation (0 available); any Fos mutation (43 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased interleukin-10 secretion ( J:175064 )
• from LPS-treated bone marrow macrophages
increased interleukin-6 secretion ( J:175064 )
• from LPS-treated bone marrow macrophages
increased tumor necrosis factor secretion ( J:175064 )
• from LPS-treated bone marrow macrophages
increased susceptibility to endotoxin shock ( J:175064 )
• LPS-treated bone marrow macrophages exhibit increased TNF-alpha and IL6 but decreased IL10 production compared with similarly treated wild-type cells




Genotype
MGI:5142272
cx2
Allelic
Composition		 Egfrwa2/Egfr+
Fostm4.1Wag/Fostm4.1Wag
Tg(KRT5-SOS1)892A6Wag/0
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Egfrwa2 mutation (3 available); any Egfr mutation (87 available)
Fostm4.1Wag mutation (0 available); any Fos mutation (43 available)
Tg(KRT5-SOS1)892A6Wag mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased skin papilloma incidence ( J:175064 )
• mice exhibit the same tumor burden as Tg(KRT5-SOS1)892A6Mka mice

integument
increased skin papilloma incidence ( J:175064 )
• mice exhibit the same tumor burden as Tg(KRT5-SOS1)892A6Mka mice




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory