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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Fostm5.1Wag
targeted mutation 5.1, Erwin F Wagner
MGI:5142240
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Fostm5.1Wag/Fostm5.1Wag involves: 129P2/OlaHsd * C57BL/6 * SJL MGI:5142263
cx2
 		Egfrwa2/Egfr+
Fostm5.1Wag/Fostm5.1Wag
Tg(KRT5-SOS1)892A6Wag/0 		involves: 129P2/OlaHsd * C57BL/6 * CBA * SJL MGI:5142267


Genotype
MGI:5142263
hm1
Allelic
Composition		 Fostm5.1Wag/Fostm5.1Wag
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fostm5.1Wag mutation (0 available); any Fos mutation (43 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal osteoclast differentiation ( J:175064 )
• osteoclast differentiation in bone marrow cultures is decreased compared to in wild-type cultures
decreased osteoclast cell number ( J:175064 )
• at 4 weeks of age
decreased interleukin-10 secretion ( J:175064 )
• from LPS-treated bone marrow macrophages
increased interleukin-6 secretion ( J:175064 )
• from LPS-treated bone marrow macrophages
increased tumor necrosis factor secretion ( J:175064 )
• from LPS-treated bone marrow macrophages
increased susceptibility to endotoxin shock ( J:175064 )
• LPS-treated bone marrow macrophages exhibit increased TNF-alpha and IL6 but decreased IL10 production compared with similarly treated wild-type cells
• LPS-treated mice exhibit increased TNF-alpha serum levels compared with similarly treated wild-type mice

skeleton
abnormal osteoclast differentiation ( J:175064 )
• osteoclast differentiation in bone marrow cultures is decreased compared to in wild-type cultures
decreased osteoclast cell number ( J:175064 )
• at 4 weeks of age
increased bone volume ( J:175064 )
• at 4, 12, and 25 weeks of age
decreased osteoblast cell number ( J:175064 )
• in bone marrow cultures
increased bone trabecula number ( J:175064 )
• at 12 weeks of age

homeostasis/metabolism

hematopoietic system
abnormal osteoclast differentiation ( J:175064 )
• osteoclast differentiation in bone marrow cultures is decreased compared to in wild-type cultures
decreased osteoclast cell number ( J:175064 )
• at 4 weeks of age

cellular
abnormal osteoclast differentiation ( J:175064 )
• osteoclast differentiation in bone marrow cultures is decreased compared to in wild-type cultures




Genotype
MGI:5142267
cx2
Allelic
Composition		 Egfrwa2/Egfr+
Fostm5.1Wag/Fostm5.1Wag
Tg(KRT5-SOS1)892A6Wag/0
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6 * CBA * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Egfrwa2 mutation (3 available); any Egfr mutation (87 available)
Fostm5.1Wag mutation (0 available); any Fos mutation (43 available)
Tg(KRT5-SOS1)892A6Wag mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
decreased tumor growth/size ( J:175064 )
• at 4 weeks, tumor volume is decreased 50% compared to in Tg(KRT5-SOS1)892A6Mka mice

integument




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory