About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Fostm6.1Wag
targeted mutation 6.1, Erwin F Wagner
MGI:5142241
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Fostm6.1Wag/Fostm6.1Wag involves: 129P2/OlaHsd * C57BL/6 * SJL MGI:5142264
cx2
 		Egfrwa2/Egfr+
Fostm6.1Wag/Fostm6.1Wag
Tg(KRT5-SOS1)892A6Wag/0 		involves: 129P2/OlaHsd * C57BL/6 * CBA * SJL MGI:5142268


Genotype
MGI:5142264
hm1
Allelic
Composition		 Fostm6.1Wag/Fostm6.1Wag
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fostm6.1Wag mutation (0 available); any Fos mutation (43 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal osteoclast differentiation ( J:175064 )
• osteoclast differentiation in bone marrow cultures is increased compared to in wild-type cultures
increased susceptibility to endotoxin shock ( J:175064 )
• LPS-treated mice exhibit increased TNF-alpha, IL6, and IL10 serum levels compared with similarly treated wild-type mice

skeleton
abnormal osteoclast differentiation ( J:175064 )
• osteoclast differentiation in bone marrow cultures is increased compared to in wild-type cultures

homeostasis/metabolism

hematopoietic system
abnormal osteoclast differentiation ( J:175064 )
• osteoclast differentiation in bone marrow cultures is increased compared to in wild-type cultures

cellular
abnormal osteoclast differentiation ( J:175064 )
• osteoclast differentiation in bone marrow cultures is increased compared to in wild-type cultures




Genotype
MGI:5142268
cx2
Allelic
Composition		 Egfrwa2/Egfr+
Fostm6.1Wag/Fostm6.1Wag
Tg(KRT5-SOS1)892A6Wag/0
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6 * CBA * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Egfrwa2 mutation (3 available); any Egfr mutation (87 available)
Fostm6.1Wag mutation (0 available); any Fos mutation (43 available)
Tg(KRT5-SOS1)892A6Wag mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased skin papilloma incidence ( J:175064 )
• papillomas are larger than in Tg(KRT5-SOS1)892A6Mka mice

integument
increased skin papilloma incidence ( J:175064 )
• papillomas are larger than in Tg(KRT5-SOS1)892A6Mka mice




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory