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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tg(KRT5-SOS1)892A6Wag
transgene insertion 892A6, Erwin F Wagner
MGI:5142254
Summary 7 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cx1
 		Egfrwa2/Egfr+
Fostm2(Fosl1)Wag/Fostm2(Fosl1)Wag
Tg(KRT5-SOS1)892A6Wag/0 		involves: 129P2/OlaHsd * C57BL/6 * CBA MGI:5142271
cx2
 		Egfrwa2/Egfr+
Fostm4.1Wag/Fostm4.1Wag
Tg(KRT5-SOS1)892A6Wag/0 		involves: 129P2/OlaHsd * C57BL/6 * CBA MGI:5142272
cx3
 		Egfrwa2/Egfr+
Fostm5.1Wag/Fostm5.1Wag
Tg(KRT5-SOS1)892A6Wag/0 		involves: 129P2/OlaHsd * C57BL/6 * CBA * SJL MGI:5142267
cx4
 		Egfrwa2/Egfr+
Fostm6.1Wag/Fostm6.1Wag
Tg(KRT5-SOS1)892A6Wag/0 		involves: 129P2/OlaHsd * C57BL/6 * CBA * SJL MGI:5142268
cx5
 		Egfrwa2/Egfr+
Fostm3.1Wag/Fostm3.1Wag
Tg(KRT5-SOS1)892A6Wag/0 		involves: 129P2/OlaHsd * C57BL/6 * CBA * SJL MGI:5142269
cx6
 		Egfrwa2/Egfr+
Rps6ka3tm1.1Kry/Y
Tg(KRT5-SOS1)892A6Wag/0 		involves: 129X1/SvJ * C57BL/6 * CBA MGI:5142270
cx7
 		Egfrwa2/Egfr+
Tg(KRT5-SOS1)892A6Wag/0 		involves: C57BL/6 * CBA MGI:5142266


Genotype
MGI:5142271
cx1
Allelic
Composition		 Egfrwa2/Egfr+
Fostm2(Fosl1)Wag/Fostm2(Fosl1)Wag
Tg(KRT5-SOS1)892A6Wag/0
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Egfrwa2 mutation (3 available); any Egfr mutation (87 available)
Fostm2(Fosl1)Wag mutation (0 available); any Fos mutation (43 available)
Tg(KRT5-SOS1)892A6Wag mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
decreased tumor growth/size ( J:175064 )
• tumor burden is reduced compared to in Tg(KRT5-SOS1)892A6Mka mice

integument




Genotype
MGI:5142272
cx2
Allelic
Composition		 Egfrwa2/Egfr+
Fostm4.1Wag/Fostm4.1Wag
Tg(KRT5-SOS1)892A6Wag/0
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Egfrwa2 mutation (3 available); any Egfr mutation (87 available)
Fostm4.1Wag mutation (0 available); any Fos mutation (43 available)
Tg(KRT5-SOS1)892A6Wag mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased skin papilloma incidence ( J:175064 )
• mice exhibit the same tumor burden as Tg(KRT5-SOS1)892A6Mka mice

integument
increased skin papilloma incidence ( J:175064 )
• mice exhibit the same tumor burden as Tg(KRT5-SOS1)892A6Mka mice




Genotype
MGI:5142267
cx3
Allelic
Composition		 Egfrwa2/Egfr+
Fostm5.1Wag/Fostm5.1Wag
Tg(KRT5-SOS1)892A6Wag/0
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6 * CBA * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Egfrwa2 mutation (3 available); any Egfr mutation (87 available)
Fostm5.1Wag mutation (0 available); any Fos mutation (43 available)
Tg(KRT5-SOS1)892A6Wag mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
decreased tumor growth/size ( J:175064 )
• at 4 weeks, tumor volume is decreased 50% compared to in Tg(KRT5-SOS1)892A6Mka mice

integument




Genotype
MGI:5142268
cx4
Allelic
Composition		 Egfrwa2/Egfr+
Fostm6.1Wag/Fostm6.1Wag
Tg(KRT5-SOS1)892A6Wag/0
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6 * CBA * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Egfrwa2 mutation (3 available); any Egfr mutation (87 available)
Fostm6.1Wag mutation (0 available); any Fos mutation (43 available)
Tg(KRT5-SOS1)892A6Wag mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased skin papilloma incidence ( J:175064 )
• papillomas are larger than in Tg(KRT5-SOS1)892A6Mka mice

integument
increased skin papilloma incidence ( J:175064 )
• papillomas are larger than in Tg(KRT5-SOS1)892A6Mka mice




Genotype
MGI:5142269
cx5
Allelic
Composition		 Egfrwa2/Egfr+
Fostm3.1Wag/Fostm3.1Wag
Tg(KRT5-SOS1)892A6Wag/0
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6 * CBA * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Egfrwa2 mutation (3 available); any Egfr mutation (87 available)
Fostm3.1Wag mutation (0 available); any Fos mutation (43 available)
Tg(KRT5-SOS1)892A6Wag mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
decreased tumor growth/size ( J:175064 )
• tumor burden is reduced compared to in Tg(KRT5-SOS1)892A6Mka mice

integument




Genotype
MGI:5142270
cx6
Allelic
Composition		 Egfrwa2/Egfr+
Rps6ka3tm1.1Kry/Y
Tg(KRT5-SOS1)892A6Wag/0
Genetic
Background		 involves: 129X1/SvJ * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Egfrwa2 mutation (3 available); any Egfr mutation (87 available)
Rps6ka3tm1.1Kry mutation (0 available); any Rps6ka3 mutation (13 available)
Tg(KRT5-SOS1)892A6Wag mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
decreased tumor growth/size ( J:175064 )
• tumor burden is reduced compared to in Tg(KRT5-SOS1)892A6Mka mice

integument




Genotype
MGI:5142266
cx7
Allelic
Composition		 Egfrwa2/Egfr+
Tg(KRT5-SOS1)892A6Wag/0
Genetic
Background		 involves: C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Egfrwa2 mutation (3 available); any Egfr mutation (87 available)
Tg(KRT5-SOS1)892A6Wag mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
integument

neoplasm




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory