Phenotypes associated with this allele

• Allele Symbol: Arhgap15^tm1Ehi
• Allele Name: targeted mutation 1, Emilio Hirsch
• Allele ID: MGI:5142283
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Arhgap15^tm1Ehi/Arhgap15^tm1Ehi	B6.129-Arhgap15^tm1Ehi	MGI:5142309

Genotype
MGI:5142309

hm1

• Allelic Composition: Arhgap15^tm1Ehi/Arhgap15^tm1Ehi
• Genetic Background: B6.129-Arhgap15^tm1Ehi

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

hematopoietic system phenotype ( J:174896 )

N • phagocyte differentiation is apparently normal

abnormal leukocyte morphology ( J:174896 )

abnormal leukocyte cell number ( J:174896 )

decreased neutrophil cell number ( J:174896 )

• reduced 36%

decreased lymphocyte cell number ( J:174896 )

• reduced 28%

decreased monocyte cell number ( J:174896 )

• monocyte/macrophage numbers reduced 43%

abnormal macrophage morphology ( J:174896 )

• bone marrow derived macrophage are more elongate in shape

• more membrane protrusions than in macrophage from controls

decreased macrophage cell number ( J:174896 )

• monocyte/macrophage numbers reduced 43%

abnormal neutrophil physiology ( J:174896 )

• increased migration toward chemoattractants

• small but significant increase in cell polarity

• increased phagocytosis of opsonized E. coli

immune system

immune system phenotype ( J:174896 )

N • chemotactic responses of bone marrow derived macrophage are normal

abnormal leukocyte morphology ( J:174896 )

abnormal leukocyte cell number ( J:174896 )

decreased neutrophil cell number ( J:174896 )

• reduced 36%

decreased lymphocyte cell number ( J:174896 )

• reduced 28%

decreased monocyte cell number ( J:174896 )

• monocyte/macrophage numbers reduced 43%

abnormal macrophage morphology ( J:174896 )

• bone marrow derived macrophage are more elongate in shape

• more membrane protrusions than in macrophage from controls

decreased macrophage cell number ( J:174896 )

• monocyte/macrophage numbers reduced 43%

abnormal neutrophil physiology ( J:174896 )

• increased migration toward chemoattractants

• small but significant increase in cell polarity

• increased phagocytosis of opsonized E. coli

decreased susceptibility to bacterial infection ( J:174896 )

• better survival from caecal ligation and perforation sepsis