All Phenotypes Mdm4<tm3.1Glo> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Mdm4^tm3.1Glo
targeted mutation 3.1, Guillermina Lozano
MGI:5142291

Summary

5 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Mdm4^tm3.1Glo/Mdm4^tm3.1Glo	involves: 129S6/SvEvTac * C57BL/6 * FVB/N	MGI:5142302
ht2	Mdm4^tm3.1Glo/Mdm4⁺	involves: 129S6/SvEvTac * C57BL/6 * FVB/N	MGI:5142306
cn3	Mdm4^tm3Glo/Mdm4^tm3.1Glo Tg(CAG-cre/Esr1*)5Amc/0	involves: 129S6/SvEvTac * C57BL/6 * CBA * FVB/N	MGI:5142305
cx4	Mdm4^tm3.1Glo/Mdm4^tm3.1Glo Trp53^tm3.1Glo/Trp53^tm3.1Glo	involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6 * FVB/N	MGI:5142303
cx5	Mdm4^tm3.1Glo/Mdm4^tm3.1Glo Trp53^tm4Glo/Trp53^tm4Glo	involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6 * FVB/N	MGI:5142304

Allelic Composition	Mdm4^tm3.1Glo/Mdm4^tm3.1Glo
Genetic Background	involves: 129S6/SvEvTac * C57BL/6 * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mdm4^tm3.1Glo mutation (0 available); any Mdm4 mutation (191 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:174368 )

• die around E9.5

Allelic Composition	Mdm4^tm3.1Glo/Mdm4⁺
Genetic Background	involves: 129S6/SvEvTac * C57BL/6 * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mdm4^tm3.1Glo mutation (0 available); any Mdm4 mutation (191 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

mortality/aging ( J:174368 )

N	• only 1 of 17 mice exposed to 6 Gy of ionizing radiation

Allelic Composition	Mdm4^tm3Glo/Mdm4^tm3.1Glo Tg(CAG-cre/Esr1*)5Amc/0
Genetic Background	involves: 129S6/SvEvTac * C57BL/6 * CBA * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mdm4^tm3.1Glo mutation (0 available); any Mdm4 mutation (191 available)
Mdm4^tm3Glo mutation (0 available); any Mdm4 mutation (191 available)
Tg(CAG-cre/Esr1*)5Amc mutation (9 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

normal phenotype

no abnormal phenotype detected ( J:174368 )

• tamoxifen treated adult mice are viable, do not appear sick, and do not display increased sensitivity to ionizing radiation

Allelic Composition	Mdm4^tm3.1Glo/Mdm4^tm3.1Glo Trp53^tm3.1Glo/Trp53^tm3.1Glo
Genetic Background	involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6 * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mdm4^tm3.1Glo mutation (0 available); any Mdm4 mutation (191 available)
Trp53^tm3.1Glo mutation (0 available); any Trp53 mutation (232 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

mortality/aging ( J:174368 )

N	• unlike mice homozygous the Mdm4 allele alone, double mutant mice are viable

Allelic Composition	Mdm4^tm3.1Glo/Mdm4^tm3.1Glo Trp53^tm4Glo/Trp53^tm4Glo
Genetic Background	involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6 * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mdm4^tm3.1Glo mutation (0 available); any Mdm4 mutation (191 available)
Trp53^tm4Glo mutation (0 available); any Trp53 mutation (232 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

mortality/aging ( J:174368 )

N	• unlike mice homozygous the Mdm4 allele alone, double mutant mice are viable

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