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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Mdm4tm3.1Glo
targeted mutation 3.1, Guillermina Lozano
MGI:5142291
Summary 5 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Mdm4tm3.1Glo/Mdm4tm3.1Glo involves: 129S6/SvEvTac * C57BL/6 * FVB/N MGI:5142302
ht2
 		Mdm4tm3.1Glo/Mdm4+ involves: 129S6/SvEvTac * C57BL/6 * FVB/N MGI:5142306
cn3
 		Mdm4tm3Glo/Mdm4tm3.1Glo
Tg(CAG-cre/Esr1*)5Amc/0 		involves: 129S6/SvEvTac * C57BL/6 * CBA * FVB/N MGI:5142305
cx4
 		Mdm4tm3.1Glo/Mdm4tm3.1Glo
Trp53tm3.1Glo/Trp53tm3.1Glo 		involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6 * FVB/N MGI:5142303
cx5
 		Mdm4tm3.1Glo/Mdm4tm3.1Glo
Trp53tm4Glo/Trp53tm4Glo 		involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6 * FVB/N MGI:5142304


Genotype
MGI:5142302
hm1
Allelic
Composition		 Mdm4tm3.1Glo/Mdm4tm3.1Glo
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mdm4tm3.1Glo mutation (0 available); any Mdm4 mutation (193 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging




Genotype
MGI:5142306
ht2
Allelic
Composition		 Mdm4tm3.1Glo/Mdm4+
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mdm4tm3.1Glo mutation (0 available); any Mdm4 mutation (193 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
mortality/aging ( J:174368 )
N
• only 1 of 17 mice exposed to 6 Gy of ionizing radiation




Genotype
MGI:5142305
cn3
Allelic
Composition		 Mdm4tm3Glo/Mdm4tm3.1Glo
Tg(CAG-cre/Esr1*)5Amc/0
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6 * CBA * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mdm4tm3.1Glo mutation (0 available); any Mdm4 mutation (193 available)
Mdm4tm3Glo mutation (0 available); any Mdm4 mutation (193 available)
Tg(CAG-cre/Esr1*)5Amc mutation (10 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:174368 )
• tamoxifen treated adult mice are viable, do not appear sick, and do not display increased sensitivity to ionizing radiation




Genotype
MGI:5142303
cx4
Allelic
Composition		 Mdm4tm3.1Glo/Mdm4tm3.1Glo
Trp53tm3.1Glo/Trp53tm3.1Glo
Genetic
Background		 involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mdm4tm3.1Glo mutation (0 available); any Mdm4 mutation (193 available)
Trp53tm3.1Glo mutation (0 available); any Trp53 mutation (240 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
mortality/aging ( J:174368 )
N
• unlike mice homozygous the Mdm4 allele alone, double mutant mice are viable




Genotype
MGI:5142304
cx5
Allelic
Composition		 Mdm4tm3.1Glo/Mdm4tm3.1Glo
Trp53tm4Glo/Trp53tm4Glo
Genetic
Background		 involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mdm4tm3.1Glo mutation (0 available); any Mdm4 mutation (193 available)
Trp53tm4Glo mutation (0 available); any Trp53 mutation (240 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
mortality/aging ( J:174368 )
N
• unlike mice homozygous the Mdm4 allele alone, double mutant mice are viable




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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory