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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Trp53tm2.1Snj
targeted mutation 2.1, Stephen N Jones
MGI:5142476
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Trp53tm2.1Snj/Trp53tm2.1Snj involves: 129S4/SvJae * C57BL/6 MGI:5142493
ht2
 		Trp53tm2.1Snj/Trp53+ involves: 129S4/SvJae * C57BL/6 MGI:5142494


Genotype
MGI:5142493
hm1
Allelic
Composition		 Trp53tm2.1Snj/Trp53tm2.1Snj
Genetic
Background		 involves: 129S4/SvJae * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Trp53tm2.1Snj mutation (0 available); any Trp53 mutation (240 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
embryonic lethality during organogenesis, incomplete penetrance ( J:175018 )
• fewer than expected mice are present at E12.5 and E14.5

cellular
abnormal cell cycle ( J:175018 )
• more mouse embryonic fibroblasts are in the S-phase compared with wild-type cells
decreased cellular sensitivity to ionizing radiation ( J:175018 )
• irradiated mouse embryonic fibroblasts exhibit a decreased reduction in S-phase populations compared with similarly treated wild-type and heterozygous cells
decreased cellular sensitivity to ultraviolet irradiation ( J:175018 )
• ultraviolet-treated mouse embryonic fibroblasts exhibit resistance to cell death compared with wild-type and Trp53tm1Brd cells
increased fibroblast proliferation ( J:175018 )
• in mouse embryonic fibroblasts
delayed cellular replicative senescence ( J:175018 )
• Ras-transfected mouse embryonic fibroblasts fail to exhibit senescence unlike similarly treated wild-type cells

nervous system
exencephaly ( J:175018 )
• in the hindbrain of 40% of mice at E9.6 to E14.5, preferentially in female mice

immune system
abnormal thymus physiology ( J:175018 )
• CD4+/CD8+ thymocytes are resistant to Trp53-mediated death unlike wild-type cells

hematopoietic system
abnormal thymus physiology ( J:175018 )
• CD4+/CD8+ thymocytes are resistant to Trp53-mediated death unlike wild-type cells

endocrine/exocrine glands
abnormal thymus physiology ( J:175018 )
• CD4+/CD8+ thymocytes are resistant to Trp53-mediated death unlike wild-type cells




Genotype
MGI:5142494
ht2
Allelic
Composition		 Trp53tm2.1Snj/Trp53+
Genetic
Background		 involves: 129S4/SvJae * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Trp53tm2.1Snj mutation (0 available); any Trp53 mutation (240 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
abnormal cell cycle ( J:175018 )
• more mouse embryonic fibroblasts are in the S-phase compared with wild-type cells
decreased cellular sensitivity to ionizing radiation ( J:175018 )
• irradiated mouse embryonic fibroblasts exhibit a decreased reduction in S-phase populations compared with similarly treated wild-type cells
increased fibroblast proliferation ( J:175018 )
• in mouse embryonic fibroblasts




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory