Phenotypes associated with this allele

• Allele Symbol: Pink1^tm1Hlw
• Allele Name: targeted mutation 1, Hung-Li Wang
• Allele ID: MGI:5142502
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Pink1^tm1Hlw/Pink1^tm1Hlw	involves: 129 * C57BL/6J	MGI:5142505

Genotype
MGI:5142505

hm1

• Allelic Composition: Pink1^tm1Hlw/Pink1^tm1Hlw
• Genetic Background: involves: 129 * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal dopaminergic neuron morphology ( J:175006 )

• substantia nigras dopaminergic neurons exhibit mitochondrial fragmentation compared unlike wild-type neurons

abnormal neuron physiology ( J:175006 )

• substantia nigras (SN) dopaminergic neurons are defective in maintaining mitochondrial membrane potential compared with wild-type cells

• SN dopaminergic neurons exhibit enhanced reactive oxygen species generation compared with wild-type cells

cellular

increased sensitivity to induced cell death ( J:175006 )

• substantia nigras neuronal cultures exhibit enhanced rotenone-induced cell death compared with similarly treated wild-type cultures

oxidative stress ( J:175006 )

• substantia nigras dopaminergic neurons exhibit enhanced reactive oxygen species generation compared with wild-type cells