Phenotypes associated with this allele

• Allele Symbol: Kcnk18^m1Ewis
• Allele Name: mutation 1, Erhard Wischmeyer
• Allele ID: MGI:5142525
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Kcnk18^m1Ewis/Kcnk18^m1Ewis	C3HeB/FeJ-Kcnk18^m1Ewis	MGI:5142528

Genotype
MGI:5142528

hm1

• Allelic Composition: Kcnk18^m1Ewis/Kcnk18^m1Ewis
• Genetic Background: C3HeB/FeJ-Kcnk18^m1Ewis

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal action potential ( J:175137 )

• duration of action potential at half-maximal amplitude is decreased compared to in wild-type cells

abnormal afterhyperpolarization ( J:175137 )

• after-hyperpolarization amplitude is increased compared to in wild-type cells

abnormal neuron physiology ( J:175137 )

• dorsal root ganglia neurons exhibit reduced potassium current amplitude compared to in wild-type cells

• neurons exhibit higher sensitivity to depolarizing stimuli compared with wild-type cells

• neurons at pH6.0 or treated with quinidine exhibit greater inhibition of potassium conductance compared with similarly treated wild-type cells

• however, bupivacaine-mediated inhibition of potassium conductance is normal