Phenotypes associated with this allele

• Allele Symbol: Fcmr^tm1.2Khl
• Allele Name: targeted mutation 1.2, Kyeong-Hee Lee
• Allele ID: MGI:5142529
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Fcmr^tm1.2Khl/Fcmr^tm1.2Khl	involves: C57BL/6	MGI:5142530

Genotype
MGI:5142530

hm1

• Allelic Composition: Fcmr^tm1.2Khl/Fcmr^tm1.2Khl
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

decreased susceptibility to xenobiotic induced morbidity/mortality ( J:174871 )

• GalN-treated mice exhibit increased survival compared with similarly treated wild-type mice

immune system

immune system phenotype ( J:174871 )

N • T cell numbers are normal

increased T cell apoptosis ( J:174871 )

• in T cells blasts stimulated with TNF

decreased B cell number ( J:174871 )

• slightly in peripheral organs

abnormal granulocyte physiology ( J:194323 )

• 50% of mutant granulocytes respond to stimulation with N-formyl-methionine-leucine-phenylalanine (fMLP) compared to 10% of control cells

homeostasis/metabolism

decreased circulating alanine transaminase level ( J:174871 )

• GalN-induced liver damage, as assessed by plasma alanine transaminase levels, and lethality are reduced compared to in similarly treated wild-type mice

decreased susceptibility to xenobiotic induced morbidity/mortality ( J:174871 )

• GalN-treated mice exhibit increased survival compared with similarly treated wild-type mice

decreased susceptibility to injury ( J:174871 )

• GalN-induced liver damage, as assessed by plasma alanine transaminase levels, and lethality are reduced compared to in similarly treated wild-type mice

hematopoietic system

increased T cell apoptosis ( J:174871 )

• in T cells blasts stimulated with TNF

decreased B cell number ( J:174871 )

• slightly in peripheral organs

abnormal granulocyte physiology ( J:194323 )

• 50% of mutant granulocytes respond to stimulation with N-formyl-methionine-leucine-phenylalanine (fMLP) compared to 10% of control cells

cellular

increased T cell apoptosis ( J:174871 )

• in T cells blasts stimulated with TNF