All Phenotypes Fads1<Gt(IST11525H2)Tigm> MGI Mouse

increased susceptibility to xenobiotic induced morbidity/mortality ( J:186265 )

• after 5 days of DSS treatment

premature death ( J:186265 )

• mice fed a diet lacking arachidonic acid begin to die at 5 to 6 weeks of age with none surviving past 12 weeks (average age of males 7.6 weeks and females 7.5 weeks)

• supplementing diet with arachidonic acid partially rescues survival

abnormal lipid level ( J:186265 )

• mice fed a diet lacking arachidonic acid exhibit reduced arachidonic acid and increased dihomo-g-linolenic acid levels in the colon mucosa, liver and splenocytes compared with wild-type mice

abnormal circulating lipid level ( J:186265 )

• mice fed a diet lacking arachidonic acid exhibit reduced arachidonic acid and increased dihomo-g-linolenic acid levels in the serum compared with wild-type mice

decreased prostaglandin level ( J:186265 )

• mice fed a diet lacking arachidonic acid exhibit lower PGE2 levels in the colonic mucosa, small intestine mucosa and lung compared with wild-type mice

increased prostaglandin level ( J:186265 )

• mice fed a diet lacking arachidonic acid exhibit higher PGE1 levels in the colonic mucosa, small intestine mucosa and lung compared with wild-type mice

increased susceptibility to xenobiotic induced morbidity/mortality ( J:186265 )

• after 5 days of DSS treatment

abnormal mononuclear cell morphology ( J:186265 )

• mice fed a diet lacking arachidonic acid exhibit reduced numbers of mononuclear cells compared with wild-type mice

decreased regulatory T cell number ( J:186265 )

• mice fed a diet lacking arachidonic acid exhibit reduced numbers of CD3+ T cells compared with wild-type mice

decreased interferon-gamma secretion ( J:186265 )

• from cultured and stimulated T cells and antibody presenting cells of mice fed a diet lacking arachidonic acid

decreased tumor necrosis factor secretion ( J:186265 )