Phenotypes associated with this allele

• Allele Symbol: Mmp25^{Gt(IST14198E10)Tigm}
• Allele Name: gene trap IST14198E10, Texas A&M Institute for Genomic Medicine
• Allele ID: MGI:5212225
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Mmp25^Gt(IST14198E10)Tigm/Mmp25^Gt(IST14198E10)Tigm	involves: C57BL/6J * C57BL/6N	MGI:7660963
hm2	Mmp25^Gt(IST14198E10)Tigm/Mmp25^Gt(IST14198E10)Tigm	involves: C57BL/6N	MGI:7660959

Genotype
MGI:7660963

hm1

• Allelic Composition: Mmp25^{Gt(IST14198E10)Tigm}/Mmp25^{Gt(IST14198E10)Tigm}
• Genetic Background: involves: C57BL/6J * C57BL/6N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal brain vasculature morphology ( J:349863 )

• partial reduction in angiogenic sprouts at E10.5 in the midbrain and forebrain

cardiovascular system

abnormal brain vasculature morphology ( J:349863 )

• partial reduction in angiogenic sprouts at E10.5 in the midbrain and forebrain

decreased angiogenesis ( J:349863 )

• partial reduction in angiogenic sprouts at E10.5 in the midbrain and forebrain

• no defects in angiogenesis are seen in peripheral organs

Genotype
MGI:7660959

hm2

• Allelic Composition: Mmp25^{Gt(IST14198E10)Tigm}/Mmp25^{Gt(IST14198E10)Tigm}
• Genetic Background: involves: C57BL/6N

hematopoietic system

abnormal neutrophil physiology ( J:347009 )

• activation by LPS stimulation is severely impaired

increased IgG level ( J:347009 )

• spontaneous

abnormal macrophage activation involved in immune response ( J:347009 )

• cultured macrophages primed with IFN-gamma and exposed to LPS show 2-fold lower nitrite production

homeostasis/metabolism

abnormal circulating cytokine level ( J:347009 )

• decreased levels of multiple proinflammatory cytokines

decreased circulating interleukin-1 alpha level ( J:347009 )

immune system

abnormal neutrophil physiology ( J:347009 )

• activation by LPS stimulation is severely impaired

increased IgG level ( J:347009 )

• spontaneous

abnormal macrophage activation involved in immune response ( J:347009 )

• cultured macrophages primed with IFN-gamma and exposed to LPS show 2-fold lower nitrite production

abnormal circulating cytokine level ( J:347009 )

• decreased levels of multiple proinflammatory cytokines

decreased circulating interleukin-1 alpha level ( J:347009 )

decreased susceptibility to endotoxin shock ( J:347009 )

• following 20 mg/kg LPS injection, survival rate is over 63% compared to approximately 23% in wild-type controls

• lung inflammatory damage and interstitial edema and markers of lung and kidney damage are reduced following LPS injection compared to wild-type controls

• wild-type mice transplanted with white blood cells from null mice show responses similar to null mice