Phenotypes associated with this allele

• Allele Symbol: Upf3b^{Gt(IST14619B5)Tigm}
• Allele Name: gene trap IST14619B5, Texas A&M Institute for Genomic Medicine
• Allele ID: MGI:5248632
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Upf3b^Gt(IST14619B5)Tigm/Upf3b^Gt(IST14619B5)Tigm	involves: C57BL/6J * C57BL/6N	MGI:6110149
ht2	Upf3b^Gt(IST14619B5)Tigm/Upf3b^+	involves: C57BL/6J * C57BL/6N	MGI:6110150
ot3	Upf3b^Gt(IST14619B5)Tigm/Y	involves: C57BL/6J * C57BL/6N	MGI:6110148

Genotype
MGI:6110149

hm1

• Allelic Composition: Upf3b^{Gt(IST14619B5)Tigm}/Upf3b^{Gt(IST14619B5)Tigm}
• Genetic Background: involves: C57BL/6J * C57BL/6N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

impaired contextual conditioning behavior ( J:253157 )

♀ • mice show decreased freezing in the context test compared to wild-type mice

impaired cued conditioning behavior ( J:253157 )

♀ • mice show decreased freezing in cued tests compared to wild-type mice

decreased startle reflex ( J:253157 )

♀ • decrease in magnitude in response to 90?110 dB(A) pulse intensities

♀ • however, response to 115 and 120 dB(A) pulses was similar to controls

♀ • haloperidol has no effect on the startle response defect

limb grasping ( J:253157 )

♀ • most mice show occasional front paw clasping

abnormal sleep duration ( J:253157 )

♀ • increase in time spent awake

abnormal sleep pattern ( J:253157 )

♀ • more frequent episodes of vigilance states that are shorter in duration compared to wild-type controls

decreased slow-wave sleep duration ( J:253157 )

♀

decreased frequency of paradoxical sleep ( J:253157 )

♀

hearing/vestibular/ear

hearing/vestibular/ear phenotype ( J:253157 )

♀N • no defect in auditory evoked potential responses at 65, 68, 70 or 80 dB

nervous system

impaired neuron differentiation ( J:253157 )

♀ • expression analysis indicates impaired differentiation of cultured neuronal precursor cells

increased neuronal precursor proliferation ( J:253157 )

♀ • cultured neuronal precursor cells show enhanced proliferation

decreased dendritic spine density ( J:253157 )

♀ • in cortical pyramidal neurons and dentate granule cells of the hippocampus

♀ • fewer mature but not immature dendritic spines in cortical pyramidal neurons

♀ • however, pyramidal neurons in the hippocampal CA1 region show normal dendritic spine densities

decreased prepulse inhibition ( J:253157 )

♀ • profound defect in PPI using 100 ms prepulse intervals and three prepulse intensities and when using a single 85 dB(A) prepulse intensity and 25-500 ms prepulse intervals

♀ • haloperidol has no effect on the PPI defect

cellular

impaired neuron differentiation ( J:253157 )

♀ • expression analysis indicates impaired differentiation of cultured neuronal precursor cells

increased neuronal precursor proliferation ( J:253157 )

♀ • cultured neuronal precursor cells show enhanced proliferation

Genotype
MGI:6110150

ht2

• Allelic Composition: Upf3b^{Gt(IST14619B5)Tigm}/Upf3b⁺
• Genetic Background: involves: C57BL/6J * C57BL/6N

behavior/neurological

impaired contextual conditioning behavior ( J:253157 )

♀ • mice show decreased freezing in the context test compared to wild-type mice but increased compared to homozygous null mice

impaired cued conditioning behavior ( J:253157 )

♀ • mice show decreased freezing in cued tests compared to wild-type mice but increased compared to homozygous null mice

Genotype
MGI:6110148

ot3

• Allelic Composition: Upf3b^{Gt(IST14619B5)Tigm}/Y
• Genetic Background: involves: C57BL/6J * C57BL/6N

behavior/neurological

impaired contextual conditioning behavior ( J:253157 )

♂ • mice show decreased freezing in the context test compared to wild-type mice

impaired cued conditioning behavior ( J:253157 )

♂ • mice show decreased freezing in cued tests compared to wild-type mice

decreased startle reflex ( J:253157 )

♂ • decrease in magnitude in response to 90?110 dB(A) pulse intensities

♂ • however, response to 115 and 120 dB(A) pulses was similar to controls

♂ • haloperidol has no effect on the startle response defect

limb grasping ( J:253157 )

♂ • most mice show occasional front paw clasping

abnormal sleep duration ( J:253157 )

♂ • increase in time spent awake

abnormal sleep pattern ( J:253157 )

♂ • more frequent episodes of vigilance states that are shorter in duration compared to wild-type controls

decreased slow-wave sleep duration ( J:253157 )

♂

decreased frequency of paradoxical sleep ( J:253157 )

♂

hearing/vestibular/ear

hearing/vestibular/ear phenotype ( J:253157 )

♂N • no defect in auditory evoked potential responses at 65, 68, 70 or 80 dB

nervous system

impaired neuron differentiation ( J:253157 )

♂ • expression analysis indicates impaired differentiation of cultured neuronal precursor cells

increased neuronal precursor proliferation ( J:253157 )

♂ • cultured neuronal precursor cells show enhanced proliferation

decreased dendritic spine density ( J:253157 )

♂ • in cortical pyramidal neurons and dentate granule cells of the hippocampus

♂ • fewer mature but not immature dendritic spines in cortical pyramidal neurons

♂ • however, pyramidal neurons in the hippocampal CA1 region show normal dendritic spine densities

decreased prepulse inhibition ( J:253157 )

♂ • profound defect in PPI using 100 ms prepulse intervals and three prepulse intensities and when using a single 85 dB(A) prepulse intensity and 25-500 ms prepulse intervals

♂ • haloperidol has no effect on the PPI defect

cellular

impaired neuron differentiation ( J:253157 )

♂ • expression analysis indicates impaired differentiation of cultured neuronal precursor cells

increased neuronal precursor proliferation ( J:253157 )

♂ • cultured neuronal precursor cells show enhanced proliferation