Phenotypes associated with this allele

• Allele Symbol: Dpysl3^{Gt(IST14728H3)Tigm}
• Allele Name: gene trap IST14728H3, Texas A&M Institute for Genomic Medicine
• Allele ID: MGI:5255169
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Dpysl3^Gt(IST14728H3)Tigm/Dpysl3^Gt(IST14728H3)Tigm	C57BL/6-Dpysl3^Gt(IST14728H3)Tigm	MGI:5751183

Genotype
MGI:5751183

hm1

• Allelic Composition: Dpysl3^{Gt(IST14728H3)Tigm}/Dpysl3^{Gt(IST14728H3)Tigm}
• Genetic Background: C57BL/6-Dpysl3^{Gt(IST14728H3)Tigm}

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

nervous system phenotype ( J:223415 )

N • no anatomical or macroscopic changes in gross brain anatomy

abnormal neuron differentiation ( J:223415 )

• hippocampal growth cones are smaller in area and exhibit a condensed central domain, numerous filopodia, small or absent lamellipodia and impaired microtubule organization compared with wild-type cells

abnormal axon extension ( J:223415 )

• cultured hippocampal neurons exhibit reduced axon out-growth and small growth cones compared with wild-type cells

• however, neurite outgrowth is normal

abnormal axonal transport ( J:223415 )

• impaired anterograde transportation

cellular

abnormal neuron differentiation ( J:223415 )

• hippocampal growth cones are smaller in area and exhibit a condensed central domain, numerous filopodia, small or absent lamellipodia and impaired microtubule organization compared with wild-type cells

abnormal axon extension ( J:223415 )

• cultured hippocampal neurons exhibit reduced axon out-growth and small growth cones compared with wild-type cells

• however, neurite outgrowth is normal