Phenotypes associated with this allele

• Allele Symbol: Etv6^{tm1.1(RUNX1,hsb5)Lvdw}
• Allele Name: targeted mutation 1.1, Louise van der Weyden
• Allele ID: MGI:5284820
• Summary: 4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Etv6^tm1.1(RUNX1,hsb5)Lvdw/Etv6^tm1.1(RUNX1,hsb5)Lvdw	involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6J	MGI:5284838
ht2	Etv6^tm1.1(RUNX1,hsb5)Lvdw/Etv6^+	involves: 129P2/OlaHsd * 129S4/SvJaeSor * 129S5/SvEvBrd * C57BL/6J	MGI:5284839
ht3	Etv6^tm1.1(RUNX1,hsb5)Lvdw/Etv6^+	involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6J	MGI:5284840
cn4	Etv6^tm1.1(RUNX1,hsb5)Lvdw/Etv6^+ TgTn(sb-T2/Onc)76Dla/0	involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6J * FVB/N	MGI:5284841

Genotype
MGI:5284838

hm1

• Allelic Composition: Etv6^{tm1.1(RUNX1,hsb5)Lvdw}/Etv6^{tm1.1(RUNX1,hsb5)Lvdw}
• Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:174866 )

• no mice are observed after E10.5

Genotype
MGI:5284839

ht2

• Allelic Composition: Etv6^{tm1.1(RUNX1,hsb5)Lvdw}/Etv6⁺
• Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * 129S5/SvEvBrd * C57BL/6J

mortality/aging

preweaning lethality, incomplete penetrance ( J:174866 )

• Background Sensitivity: fewer than expected mice are produced with increased C57BL/6J background contribution

Genotype
MGI:5284840

ht3

• Allelic Composition: Etv6^{tm1.1(RUNX1,hsb5)Lvdw}/Etv6⁺
• Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6J

neoplasm

increased leukemia incidence ( J:174866 )

• 68% of mice develop T-cell acute lymphocytic leukemia with occasional cases of acute myeloid leukemia and B-cell precursor acute lymphoblastic leukemia (BCP-ALL; 13%)

Genotype
MGI:5284841

cn4

• Allelic Composition: Etv6^{tm1.1(RUNX1,hsb5)Lvdw}/Etv6⁺; TgTn(sb-T2/Onc)76Dla/0
• Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6J * FVB/N

mortality/aging

premature death ( J:174866 )

• mice exhibit increased decreased survival compared with control mice

neoplasm

increased leukemia incidence ( J:174866 )

• mice exhibit increased incidence of leukemia compared with control mice

• predominantly acute myeloid leukemia (AML; 46%) with some T cell acute lymphocytic leukemia (T-ALL; 28%) and B-cell precursor acute lymphoblastic leukemia (BCP-ALL; 21%)

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
acute lymphoblastic leukemia		DOID:9952	OMIM:247640 OMIM:613065	J:174866