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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Stat1tm1Uvin
targeted mutation 1, Uwe Vinkemeier
MGI:5284857
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Stat1tm1Uvin/Stat1tm1Uvin involves: 129 * C57BL/6 MGI:5284865


Genotype
MGI:5284865
hm1
Allelic
Composition		 Stat1tm1Uvin/Stat1tm1Uvin
Genetic
Background		 involves: 129 * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Stat1tm1Uvin mutation (0 available); any Stat1 mutation (74 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
increased macrophage nitric oxide production ( J:174863 )
• IFN-gamma- or LPS-treated macrophages exhibit robust NO production unlike similarly treated wild-type cells
• macrophage treated with IFN-gamma and LPS (1 ng/ml) exhibit increased NO production compared with similarly treated wild-type cells

immune system
increased macrophage nitric oxide production ( J:174863 )
• IFN-gamma- or LPS-treated macrophages exhibit robust NO production unlike similarly treated wild-type cells
• macrophage treated with IFN-gamma and LPS (1 ng/ml) exhibit increased NO production compared with similarly treated wild-type cells

hematopoietic system
increased macrophage nitric oxide production ( J:174863 )
• IFN-gamma- or LPS-treated macrophages exhibit robust NO production unlike similarly treated wild-type cells
• macrophage treated with IFN-gamma and LPS (1 ng/ml) exhibit increased NO production compared with similarly treated wild-type cells




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory