Phenotypes associated with this allele

• Allele Symbol: Trpm2^tm1.1Alp
• Allele Name: targeted mutation 1.1, Anne-Laure Perraud
• Allele ID: MGI:5284866
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Trpm2^tm1.1Alp/Trpm2^tm1.1Alp	B6.129P2-Trpm2^tm1.1Alp	MGI:5284869

Genotype
MGI:5284869

hm1

• Allelic Composition: Trpm2^tm1.1Alp/Trpm2^tm1.1Alp
• Genetic Background: B6.129P2-Trpm2^tm1.1Alp

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Trpm2^tm1.1Alp/Trpm2^tm1.1Alp and Ifngr1^tm1Agt/Ifngr1^tm1Agt mice exhibit increased susceptibility to bacterial infection

mortality/aging

increased susceptibility to bacterial infection induced morbidity/mortality ( J:174397 )

• in mice infected with Listeria monocytogenes compared with similarly treated wild-type mice and Il12rb2^tm1Jm homozygotes

• in mice infected with low-dose Listeria monocytogenes and treated with anti-IL12b antibodies

• however, mice exhibit normal survival in response to low doses Lm infection unlike Ifngr1^tm1Agt homozygotes

• however, IFN-gamma treatment reverses increased susceptibility to high-dose Lm infection

immune system

decreased circulating interferon-gamma level ( J:174397 )

decreased circulating interleukin-12 level ( J:174397 )

• in mice infected with Listeria monocytogenes

decreased circulating interleukin-12b level ( J:174397 )

• in mice infected with Listeria monocytogenes

decreased interferon-gamma secretion ( J:174397 )

• in CD8+ T and NK cells of mice infected with Listeria monocytogenes (Lm)

• in splenocytes from mice infected with heat killed (Lm)

• however, lymphocytes stimulated by IL12 and IL18 exhibit normal IFN-gamma production

decreased interleukin-12 secretion ( J:174397 )

• in conventional dendritic cells or macrophage of mice infected with Listeria monocytogenes (Lm)

• in splenocytes from mice infected with heat killed (Lm)

increased susceptibility to bacterial infection ( J:174397 )

• mice infected with Listeria monocytogenes (Lm) exhibit decreased survival and cytokine serum levels (IFN-gamma, IL12, and IL12b) and production (IFN-gamma and IL12), increased bacterial burden in the spleen and liver, and increased numbers of inflammatory abscesses in the liver with parenchyma destruction and necrosis in perivascular regions compared with similarly treated wild-type mice

• however, Lm-infected mice exhibit normal IL6 serum levels and mice exhibit normal survival in response to low doses Lm infection unlike Ifngr1^tm1Agt homozygotes

• however, IFN-gamma treatment reverses increased susceptibility to high-dose Lm infection

increased susceptibility to bacterial infection induced morbidity/mortality ( J:174397 )

• in mice infected with Listeria monocytogenes compared with similarly treated wild-type mice and Il12rb2^tm1Jm homozygotes

• in mice infected with low-dose Listeria monocytogenes and treated with anti-IL12b antibodies

• however, mice exhibit normal survival in response to low doses Lm infection unlike Ifngr1^tm1Agt homozygotes

• however, IFN-gamma treatment reverses increased susceptibility to high-dose Lm infection

liver/biliary system

liver abscess ( J:174397 )

• greater in mice infected with Listeria monocytogenes than in similarly treated wild-type mice

homeostasis/metabolism

decreased circulating interferon-gamma level ( J:174397 )

decreased circulating interleukin-12 level ( J:174397 )

• in mice infected with Listeria monocytogenes

decreased circulating interleukin-12b level ( J:174397 )

• in mice infected with Listeria monocytogenes