Phenotypes associated with this allele

• Allele Symbol: Adam17^tm1Rain
• Allele Name: targeted mutation 1, Elaine Raines
• Allele ID: MGI:5284875
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Adam17^tm1Rain/Adam17^tm1Rain	involves: C57BL/6	MGI:5284895

Genotype
MGI:5284895

hm1

• Allelic Composition: Adam17^tm1Rain/Adam17^tm1Rain
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

enhanced leukocyte tethering or rolling ( J:174865 )

• in a model of sterile peritonitis irradiated, wild-type mice reconstituted with fetal liver cells exhibit accelerated neutrophil recruitment compared to in wild-type mice reconstituted with wild-type cells

• in vivo, irradiated wild-type mice reconstituted with fetal liver cells exhibit decreased leukocyte rolling velocity and increased adhesion compared to in wild-type mice reconstituted with wild-type cells

homeostasis/metabolism

decreased physiological sensitivity to xenobiotic ( J:174865 )

• irradiated wild-type mice reconstituted with fetal liver cells fail to exhibit an increase in peritoneal neutrophils in response to treatment with hydroxamate inhibitor unlike similarly treated wild-type mice reconstituted with wild-type cells

cellular

enhanced leukocyte tethering or rolling ( J:174865 )

• in a model of sterile peritonitis irradiated, wild-type mice reconstituted with fetal liver cells exhibit accelerated neutrophil recruitment compared to in wild-type mice reconstituted with wild-type cells

• in vivo, irradiated wild-type mice reconstituted with fetal liver cells exhibit decreased leukocyte rolling velocity and increased adhesion compared to in wild-type mice reconstituted with wild-type cells

hematopoietic system

enhanced leukocyte tethering or rolling ( J:174865 )

• in a model of sterile peritonitis irradiated, wild-type mice reconstituted with fetal liver cells exhibit accelerated neutrophil recruitment compared to in wild-type mice reconstituted with wild-type cells

• in vivo, irradiated wild-type mice reconstituted with fetal liver cells exhibit decreased leukocyte rolling velocity and increased adhesion compared to in wild-type mice reconstituted with wild-type cells