mortality/aging
• newborns die within hours of birth
|
• 65% of mice die between E12.5 and E13.5
|
nervous system
• in some mice that die between E12.5 and E13.5
|
exencephaly
(
J:175212
)
• hindbrain
|
cellular
• in mouse embryonic fibroblasts
|
• mouse embryonic fibroblasts produce normal amounts of hydrogen peroxide than wild-type cells
• however, hydrogen peroxide production in fetal liver cells is normal
|
cardiovascular system
embryo
• in some mice that die between E12.5 and E13.5
|
• in some mice that die between E12.5 and E13.5
|
vision/eye
liver/biliary system
N |
• mice exhibit normal liver development
|
growth/size/body
• in some mice that die between E12.5 and E13.5
|