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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Cdkn1atm1Hpw
targeted mutation 1, Helen Piwnica-Worms
MGI:5285186
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Cdkn1atm1Hpw/Cdkn1atm1Hpw involves: 129X1/SvJ MGI:5502588
cx2
 		Cdkn1atm1Hpw/Cdkn1a+
Trp53tm2Wahl/Trp53tm2Wahl 		involves: 129S4/SvJae * 129X1/SvJ * C57BL/6 MGI:5285193


Genotype
MGI:5502588
hm1
Allelic
Composition		 Cdkn1atm1Hpw/Cdkn1atm1Hpw
Genetic
Background		 involves: 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdkn1atm1Hpw mutation (1 available); any Cdkn1a mutation (63 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
growth/size/body
growth/size/body region phenotype ( J:199432 )
N
• fasted mice exhibit no significant change in weight

homeostasis/metabolism
homeostasis/metabolism phenotype ( J:199432 )
N
• fed and fasted mice exhibit normal ability of glucose to be stored as glycogen in the liver




Genotype
MGI:5285193
cx2
Allelic
Composition		 Cdkn1atm1Hpw/Cdkn1a+
Trp53tm2Wahl/Trp53tm2Wahl
Genetic
Background		 involves: 129S4/SvJae * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdkn1atm1Hpw mutation (1 available); any Cdkn1a mutation (63 available)
Trp53tm2Wahl mutation (0 available); any Trp53 mutation (240 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
decreased mortality induced by ionizing radiation ( J:174375 )
• compared with irradiated Trp53tm2Wahl homozygotes

homeostasis/metabolism
decreased mortality induced by ionizing radiation ( J:174375 )
• compared with irradiated Trp53tm2Wahl homozygotes




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory