All Phenotypes Sox11<tm1.2Vlf> MGI Mouse

About Help FAQ

Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Sox11^tm1.2Vlf
targeted mutation 1.2, Veronique Lefebvre
MGI:5285292

Summary

9 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Sox11^tm1.2Vlf/Sox11^tm1.2Vlf	involves: 129 * C57BL/6	MGI:5285382
cn2	Sox11^tm1.2Vlf/Sox11^tm1.2Vlf Sox4^tm1Vlf/Sox4^tm1Vlf Tg(Pou3f4-cre)32Cren/0	involves: 129 * C57BL/6 * CD-1 * FVB/N	MGI:5285374
cx3	Sox11^tm1.2Vlf/Sox11⁺ Sox4^tm1.1Vlf/Sox4⁺ Tead2^tm1Hssk/Tead2^tm1Hssk	involves: 129 * C57BL/6 * CBA * FVB/N	MGI:5285372
cx4	Sox11^tm1.2Vlf/Sox11⁺ Sox4^tm1.1Vlf/Sox4^tm1.1Vlf	involves: 129 * C57BL/6 * FVB/N	MGI:5285371
cx5	Sox11^tm1.2Vlf/Sox11⁺ Sox4^tm1.1Vlf/Sox4⁺	involves: 129 * C57BL/6 * FVB/N	MGI:5285373
cx6	Sox11^tm1.2Vlf/Sox11^tm1.2Vlf Sox4^tm1.1Vlf/Sox4⁺	involves: 129 * C57BL/6 * FVB/N	MGI:5285378
cx7	Sox11^tm1.2Vlf/Sox11^tm1.2Vlf Sox4^tm1.1Vlf/Sox4^tm1.1Vlf	involves: 129 * C57BL/6 * FVB/N	MGI:5285379
cx8	Sox11^tm1.2Vlf/Sox11⁺ Sox12^tm1.1Vlf/Sox12^tm1.1Vlf Sox4^tm1.1Vlf/Sox4⁺	involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6	MGI:5285380
cx9	Sox11^tm1.2Vlf/Sox11^tm1.2Vlf Sox12^tm1.1Vlf/Sox12^tm1.1Vlf Sox4^tm1.1Vlf/Sox4^tm1.1Vlf	involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6	MGI:5285381

Allelic Composition	Sox11^tm1.2Vlf/Sox11^tm1.2Vlf
Genetic Background	involves: 129 * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sox11^tm1.2Vlf mutation (0 available); any Sox11 mutation (15 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

perinatal lethality, complete penetrance ( J:175338 )

• mice die on birth

skeleton

abnormal cranium morphology ( J:175338 )

• hypomineralized skull with wide sutures

wide cranial sutures ( J:175338 )

abnormal sternebra morphology ( J:175338 )

• hypoplastic

• the last two or three sternebrae are misshapen and irregularly mineralized

sternebra fusion ( J:175338 )

abnormal xiphoid process morphology ( J:175338 )

• the xiphoid process is misshapen and irregularly mineralized

abnormal vertebrae morphology ( J:175338 )

• vertebral body duplication in some mice

abnormal lumbar vertebrae morphology ( J:175338 )

• unfused lumbar vertebral bodies

• L4 and L5 are duplicated

abnormal bone mineralization ( J:175338 )

• hypomineralized skull

• the last two or three sternebrae and the xiphoid process are irregularly mineralized

cardiovascular system

persistent truncus arteriosus ( J:175338 )

abnormal heart development ( J:175338 )

• mice exhibit incomplete septation of the heart ventricles unlike wild-type mice

double outlet right ventricle ( J:175338 )

vision/eye

microphthalmia ( J:175338 )

• in all mice

eyelids open at birth ( J:175338 )

• in all mice

craniofacial

abnormal cranium morphology ( J:175338 )

• hypomineralized skull with wide sutures

wide cranial sutures ( J:175338 )

cleft upper lip ( J:175338 )

• 40% of mice exhibit cleft palate, cleft lips, and kinked tails

cleft palate ( J:175338 )

• 40% of mice exhibit cleft palate, cleft lips, and kinked tails

hematopoietic system

absent spleen ( J:175338 )

• in all mice

growth/size/body

cleft upper lip ( J:175338 )

• 40% of mice exhibit cleft palate, cleft lips, and kinked tails

cleft palate ( J:175338 )

• 40% of mice exhibit cleft palate, cleft lips, and kinked tails

omphalocele ( J:175338 )

• in 50% of mice

digestive/alimentary system

cleft palate ( J:175338 )

• 40% of mice exhibit cleft palate, cleft lips, and kinked tails

immune system

absent spleen ( J:175338 )

• in all mice

limbs/digits/tail

kinked tail ( J:175338 )

• 40% of mice exhibit cleft palate, cleft lips, and kinked tails

Allelic Composition	Sox11^tm1.2Vlf/Sox11^tm1.2Vlf Sox4^tm1Vlf/Sox4^tm1Vlf Tg(Pou3f4-cre)32Cren/0
Genetic Background	involves: 129 * C57BL/6 * CD-1 * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sox11^tm1.2Vlf mutation (0 available); any Sox11 mutation (15 available)
Sox4^tm1Vlf mutation (0 available); any Sox4 mutation (23 available)
Tg(Pou3f4-cre)32Cren mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

embryo

abnormal neural tube morphology ( J:175338 )

• increased cell death without a decrease in cell proliferation

nervous system

abnormal neural tube morphology ( J:175338 )

• increased cell death without a decrease in cell proliferation

Allelic Composition	Sox11^tm1.2Vlf/Sox11⁺ Sox4^tm1.1Vlf/Sox4⁺ Tead2^tm1Hssk/Tead2^tm1Hssk
Genetic Background	involves: 129 * C57BL/6 * CBA * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sox11^tm1.2Vlf mutation (0 available); any Sox11 mutation (15 available)
Sox4^tm1.1Vlf mutation (0 available); any Sox4 mutation (23 available)
Tead2^tm1Hssk mutation (1 available); any Tead2 mutation (34 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

double outlet right ventricle ( J:175338 )

• higher incident than in Tead2^tm1Hssk homozygotes and Sox4^tm1.1Vlf Sox11^tm2.2Weg heterozygotes

ventricular septal defect ( J:175338 )

• higher incident than in Tead2^tm1Hssk homozygotes and Sox4^tm1.1Vlf Sox11^tm2.2Weg heterozygotes

embryo

abnormal notochord morphology ( J:175338 )

• at E11.5, mice exhibit cell death around the notochord in the lumbar, but not thoracic, region compared with wild-type mice

skeleton

abnormal vertebrae morphology ( J:175338 )

• more severe and more frequent than in Tead2^tm1Hssk homozygotes and Sox4^tm1.1Vlf Sox11^tm2.2Weg heterozygotes

Allelic Composition	Sox11^tm1.2Vlf/Sox11⁺ Sox4^tm1.1Vlf/Sox4^tm1.1Vlf
Genetic Background	involves: 129 * C57BL/6 * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sox11^tm1.2Vlf mutation (0 available); any Sox11 mutation (15 available)
Sox4^tm1.1Vlf mutation (0 available); any Sox4 mutation (23 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:175338 )

• mice die around E10.5

nervous system

open neural tube ( J:175338 )

cardiovascular system

failure of heart looping ( J:175338 )

• at E9.5, mice lack heart coiling unlike wild-type mice

craniofacial

abnormal pharyngeal arch mesenchyme morphology ( J:175338 )

• branchial arch mesenchyme is loose and small compared to in wild-type mice

embryo

abnormal pharyngeal arch mesenchyme morphology ( J:175338 )

• branchial arch mesenchyme is loose and small compared to in wild-type mice

incomplete embryo turning ( J:175338 )

• at E9.5

decreased embryo size ( J:175338 )

• at E9.5

open neural tube ( J:175338 )

growth/size/body

abnormal pharyngeal arch mesenchyme morphology ( J:175338 )

• branchial arch mesenchyme is loose and small compared to in wild-type mice

decreased embryo size ( J:175338 )

• at E9.5

Allelic Composition	Sox11^tm1.2Vlf/Sox11⁺ Sox4^tm1.1Vlf/Sox4⁺
Genetic Background	involves: 129 * C57BL/6 * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sox11^tm1.2Vlf mutation (0 available); any Sox11 mutation (15 available)
Sox4^tm1.1Vlf mutation (0 available); any Sox4 mutation (23 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

perinatal lethality, complete penetrance ( J:175338 )

• mice die on birth

skeleton

abnormal cranium morphology ( J:175338 )

• hypomineralized skull with wide sutures

wide cranial sutures ( J:175338 )

abnormal sternebra morphology ( J:175338 )

• hypoplastic

• the last two or three sternebrae are misshapen and irregularly mineralized

sternebra fusion ( J:175338 )

abnormal xiphoid process morphology ( J:175338 )

• the xiphoid process is misshapen and irregularly mineralized

abnormal lumbar vertebrae morphology ( J:175338 )

• unfused lumbar vertebral bodies

• L4 and L5 are duplicated

abnormal bone mineralization ( J:175338 )

• hypomineralized skull

• the last two or three sternebrae and the xiphoid process are irregularly mineralized

cardiovascular system

double outlet right ventricle ( J:175338 )

ventricular septal defect ( J:175338 )

• incomplete ventricular septation

vision/eye

vision/eye phenotype ( J:175338 )

N	• mice exhibit normal eyes

craniofacial

craniofacial phenotype ( J:175338 )

N	• mice exhibit normal palate and lip formation

abnormal cranium morphology ( J:175338 )

• hypomineralized skull with wide sutures

wide cranial sutures ( J:175338 )

hematopoietic system

small spleen ( J:175338 )

• in 60% of mice

immune system

small spleen ( J:175338 )

• in 60% of mice

growth/size/body

omphalocele ( J:175338 )

• in 50% of mice in one of 2 crosses

Allelic Composition	Sox11^tm1.2Vlf/Sox11^tm1.2Vlf Sox4^tm1.1Vlf/Sox4⁺
Genetic Background	involves: 129 * C57BL/6 * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sox11^tm1.2Vlf mutation (0 available); any Sox11 mutation (15 available)
Sox4^tm1.1Vlf mutation (0 available); any Sox4 mutation (23 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

lethality throughout fetal growth and development, complete penetrance ( J:175338 )

• mice die between E14.5 and E16.5

cardiovascular system

myocardium hypoplasia ( J:175338 )

• hypoplastic myocardium

persistent truncus arteriosus ( J:175338 )

semilunar valve hypoplasia ( J:175338 )

• hypoplastic semilunar valves

skeleton

micrognathia ( J:175338 )

• at E17.5

sternum hypoplasia ( J:175338 )

• at E17.5

abnormal skeleton development ( J:175338 )

• underdeveloped

vision/eye

aphakia ( J:175338 )

• at E17.5

abnormal eye development ( J:175338 )

• underdeveloped

microphthalmia ( J:175338 )

• at E17.5

eyelids open at birth ( J:175338 )

respiratory system

abnormal lung development ( J:175338 )

• underdeveloped

small lung ( J:175338 )

• at E17.5

craniofacial

micrognathia ( J:175338 )

• at E17.5

homeostasis/metabolism

edema ( J:175338 )

• generalized at E17.5

muscle

myocardium hypoplasia ( J:175338 )

• hypoplastic myocardium

Allelic Composition	Sox11^tm1.2Vlf/Sox11^tm1.2Vlf Sox4^tm1.1Vlf/Sox4^tm1.1Vlf
Genetic Background	involves: 129 * C57BL/6 * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sox11^tm1.2Vlf mutation (0 available); any Sox11 mutation (15 available)
Sox4^tm1.1Vlf mutation (0 available); any Sox4 mutation (23 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:175338 )

• mice die around E10.5

nervous system

abnormal neural tube morphology ( J:175338 )

• thin at E9.5

• increased cell death and decreased cell proliferation

incomplete rostral neuropore closure ( J:175338 )

• rostrally open neural tube at E9.5

wavy neural tube ( J:175338 )

• undulated neural tube at E9.5

cardiovascular system

abnormal heart development ( J:175338 )

• unfused heart primordia at E9.5

cardia bifida ( J:175338 )

• at E9.5

cellular

abnormal cell death ( J:175338 )

• at E9.5, mice exhibit increased cell death in the neural tube, branchial arches, and somites unlike in wild-type mice

decreased cell proliferation ( J:175338 )

• cell proliferation in the neural tube, branchial arches, and somites is reduced compared to in wild-type mice

craniofacial

abnormal pharyngeal arch mesenchyme morphology ( J:175338 )

• branchial arch mesenchyme is loose and small compared to in wild-type mice

embryo

abnormal pharyngeal arch mesenchyme morphology ( J:175338 )

• branchial arch mesenchyme is loose and small compared to in wild-type mice

incomplete embryo turning ( J:175338 )

• at E9.5

abnormal pharyngeal arch development ( J:175338 )

• increased cell death and decreased cell proliferation

embryonic growth arrest ( J:175338 )

• at E8.5

decreased embryo size ( J:175338 )

• at E9.5

absent limb buds ( J:175338 )

• limbs fail to bud

abnormal neural tube morphology ( J:175338 )

• thin at E9.5

• increased cell death and decreased cell proliferation

incomplete rostral neuropore closure ( J:175338 )

• rostrally open neural tube at E9.5

wavy neural tube ( J:175338 )

• undulated neural tube at E9.5

impaired somite development ( J:175338 )

• rudimentary with increased cell death and decreased cell proliferation

growth/size/body

abnormal pharyngeal arch mesenchyme morphology ( J:175338 )

• branchial arch mesenchyme is loose and small compared to in wild-type mice

decreased embryo size ( J:175338 )

• at E9.5

limbs/digits/tail

absent limb buds ( J:175338 )

• limbs fail to bud

Allelic Composition	Sox11^tm1.2Vlf/Sox11⁺ Sox12^tm1.1Vlf/Sox12^tm1.1Vlf Sox4^tm1.1Vlf/Sox4⁺
Genetic Background	involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sox11^tm1.2Vlf mutation (0 available); any Sox11 mutation (15 available)
Sox12^tm1.1Vlf mutation (0 available); any Sox12 mutation (8 available)
Sox4^tm1.1Vlf mutation (0 available); any Sox4 mutation (23 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

persistent truncus arteriosus ( J:175338 )

double outlet right ventricle ( J:175338 )

ventricular septal defect ( J:175338 )

• incomplete ventricular septation

skeleton

abnormal cranium morphology ( J:175338 )

• hypomineralized skull

abnormal sternebra morphology ( J:175338 )

• fusion and /or deletion

• split sternal bars in all mice

sternebra fusion ( J:175338 )

abnormal vertebrae morphology ( J:175338 )

• vertebral body duplication in all mice

abnormal bone mineralization ( J:175338 )

• hypomineralized skull

craniofacial

abnormal cranium morphology ( J:175338 )

• hypomineralized skull

immune system

small spleen ( J:175338 )

• in all mice

hematopoietic system

small spleen ( J:175338 )

• in all mice

Allelic Composition	Sox11^tm1.2Vlf/Sox11^tm1.2Vlf Sox12^tm1.1Vlf/Sox12^tm1.1Vlf Sox4^tm1.1Vlf/Sox4^tm1.1Vlf
Genetic Background	involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sox11^tm1.2Vlf mutation (0 available); any Sox11 mutation (15 available)
Sox12^tm1.1Vlf mutation (0 available); any Sox12 mutation (8 available)
Sox4^tm1.1Vlf mutation (0 available); any Sox4 mutation (23 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

embryo

abnormal neural tube morphology ( J:175338 )

• thin

• more severe than in Sox4^tm1.1Vlf Sox11^tm2.2Weg double homozygotes

kinked neural tube ( J:175338 )

• more severe than in Sox4^tm1.1Vlf Sox11^tm2.2Weg double homozygotes

nervous system

abnormal neural tube morphology ( J:175338 )

• thin

• more severe than in Sox4^tm1.1Vlf Sox11^tm2.2Weg double homozygotes

kinked neural tube ( J:175338 )

• more severe than in Sox4^tm1.1Vlf Sox11^tm2.2Weg double homozygotes

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 10/29/2024 MGI 6.24