All Phenotypes Sox11<tm1.2Vlf> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Sox11^tm1.2Vlf
targeted mutation 1.2, Veronique Lefebvre
MGI:5285292

Summary

9 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Sox11^tm1.2Vlf/Sox11^tm1.2Vlf	involves: 129 * C57BL/6	MGI:5285382
cn2	Sox11^tm1.2Vlf/Sox11^tm1.2Vlf Sox4^tm1Vlf/Sox4^tm1Vlf Tg(Pou3f4-cre)32Cren/0	involves: 129 * C57BL/6 * CD-1 * FVB/N	MGI:5285374
cx3	Sox11^tm1.2Vlf/Sox11⁺ Sox4^tm1.1Vlf/Sox4⁺ Tead2^tm1Hssk/Tead2^tm1Hssk	involves: 129 * C57BL/6 * CBA * FVB/N	MGI:5285372
cx4	Sox11^tm1.2Vlf/Sox11⁺ Sox4^tm1.1Vlf/Sox4^tm1.1Vlf	involves: 129 * C57BL/6 * FVB/N	MGI:5285371
cx5	Sox11^tm1.2Vlf/Sox11⁺ Sox4^tm1.1Vlf/Sox4⁺	involves: 129 * C57BL/6 * FVB/N	MGI:5285373
cx6	Sox11^tm1.2Vlf/Sox11^tm1.2Vlf Sox4^tm1.1Vlf/Sox4⁺	involves: 129 * C57BL/6 * FVB/N	MGI:5285378
cx7	Sox11^tm1.2Vlf/Sox11^tm1.2Vlf Sox4^tm1.1Vlf/Sox4^tm1.1Vlf	involves: 129 * C57BL/6 * FVB/N	MGI:5285379
cx8	Sox11^tm1.2Vlf/Sox11⁺ Sox12^tm1.1Vlf/Sox12^tm1.1Vlf Sox4^tm1.1Vlf/Sox4⁺	involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6	MGI:5285380
cx9	Sox11^tm1.2Vlf/Sox11^tm1.2Vlf Sox12^tm1.1Vlf/Sox12^tm1.1Vlf Sox4^tm1.1Vlf/Sox4^tm1.1Vlf	involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6	MGI:5285381

Allelic Composition	Sox11^tm1.2Vlf/Sox11^tm1.2Vlf
Genetic Background	involves: 129 * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sox11^tm1.2Vlf mutation (0 available); any Sox11 mutation (15 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

perinatal lethality, complete penetrance ( J:175338 )

• mice die on birth

skeleton

abnormal cranium morphology ( J:175338 )

• hypomineralized skull with wide sutures

wide cranial sutures ( J:175338 )

abnormal sternebra morphology ( J:175338 )

• hypoplastic

• the last two or three sternebrae are misshapen and irregularly mineralized

sternebra fusion ( J:175338 )

abnormal xiphoid process morphology ( J:175338 )

• the xiphoid process is misshapen and irregularly mineralized

abnormal vertebrae morphology ( J:175338 )

• vertebral body duplication in some mice

abnormal lumbar vertebrae morphology ( J:175338 )

• unfused lumbar vertebral bodies

• L4 and L5 are duplicated

abnormal bone mineralization ( J:175338 )

• hypomineralized skull

• the last two or three sternebrae and the xiphoid process are irregularly mineralized

cardiovascular system

persistent truncus arteriosus ( J:175338 )

abnormal heart development ( J:175338 )

• mice exhibit incomplete septation of the heart ventricles unlike wild-type mice

double outlet right ventricle ( J:175338 )

vision/eye

microphthalmia ( J:175338 )

• in all mice

eyelids open at birth ( J:175338 )

• in all mice

craniofacial

abnormal cranium morphology ( J:175338 )

• hypomineralized skull with wide sutures

wide cranial sutures ( J:175338 )

cleft upper lip ( J:175338 )

• 40% of mice exhibit cleft palate, cleft lips, and kinked tails

cleft palate ( J:175338 )

• 40% of mice exhibit cleft palate, cleft lips, and kinked tails

hematopoietic system

absent spleen ( J:175338 )

• in all mice

growth/size/body

cleft upper lip ( J:175338 )

• 40% of mice exhibit cleft palate, cleft lips, and kinked tails

cleft palate ( J:175338 )

• 40% of mice exhibit cleft palate, cleft lips, and kinked tails

omphalocele ( J:175338 )

• in 50% of mice

digestive/alimentary system

cleft palate ( J:175338 )

• 40% of mice exhibit cleft palate, cleft lips, and kinked tails

immune system

absent spleen ( J:175338 )

• in all mice

limbs/digits/tail

kinked tail ( J:175338 )

• 40% of mice exhibit cleft palate, cleft lips, and kinked tails

Allelic Composition	Sox11^tm1.2Vlf/Sox11^tm1.2Vlf Sox4^tm1Vlf/Sox4^tm1Vlf Tg(Pou3f4-cre)32Cren/0
Genetic Background	involves: 129 * C57BL/6 * CD-1 * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sox11^tm1.2Vlf mutation (0 available); any Sox11 mutation (15 available)
Sox4^tm1Vlf mutation (0 available); any Sox4 mutation (23 available)
Tg(Pou3f4-cre)32Cren mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

embryo

abnormal neural tube morphology ( J:175338 )

• increased cell death without a decrease in cell proliferation

nervous system

abnormal neural tube morphology ( J:175338 )

• increased cell death without a decrease in cell proliferation

Allelic Composition	Sox11^tm1.2Vlf/Sox11⁺ Sox4^tm1.1Vlf/Sox4⁺ Tead2^tm1Hssk/Tead2^tm1Hssk
Genetic Background	involves: 129 * C57BL/6 * CBA * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sox11^tm1.2Vlf mutation (0 available); any Sox11 mutation (15 available)
Sox4^tm1.1Vlf mutation (0 available); any Sox4 mutation (23 available)
Tead2^tm1Hssk mutation (1 available); any Tead2 mutation (34 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

double outlet right ventricle ( J:175338 )

• higher incident than in Tead2^tm1Hssk homozygotes and Sox4^tm1.1Vlf Sox11^tm2.2Weg heterozygotes

ventricular septal defect ( J:175338 )

• higher incident than in Tead2^tm1Hssk homozygotes and Sox4^tm1.1Vlf Sox11^tm2.2Weg heterozygotes

embryo

abnormal notochord morphology ( J:175338 )

• at E11.5, mice exhibit cell death around the notochord in the lumbar, but not thoracic, region compared with wild-type mice

skeleton

abnormal vertebrae morphology ( J:175338 )

• more severe and more frequent than in Tead2^tm1Hssk homozygotes and Sox4^tm1.1Vlf Sox11^tm2.2Weg heterozygotes

Allelic Composition	Sox11^tm1.2Vlf/Sox11⁺ Sox4^tm1.1Vlf/Sox4^tm1.1Vlf
Genetic Background	involves: 129 * C57BL/6 * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sox11^tm1.2Vlf mutation (0 available); any Sox11 mutation (15 available)
Sox4^tm1.1Vlf mutation (0 available); any Sox4 mutation (23 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:175338 )

• mice die around E10.5

nervous system

open neural tube ( J:175338 )

cardiovascular system

failure of heart looping ( J:175338 )

• at E9.5, mice lack heart coiling unlike wild-type mice

craniofacial

abnormal pharyngeal arch mesenchyme morphology ( J:175338 )

• branchial arch mesenchyme is loose and small compared to in wild-type mice

embryo

abnormal pharyngeal arch mesenchyme morphology ( J:175338 )

• branchial arch mesenchyme is loose and small compared to in wild-type mice

incomplete embryo turning ( J:175338 )

• at E9.5

decreased embryo size ( J:175338 )

• at E9.5

open neural tube ( J:175338 )

growth/size/body

abnormal pharyngeal arch mesenchyme morphology ( J:175338 )

• branchial arch mesenchyme is loose and small compared to in wild-type mice

decreased embryo size ( J:175338 )

• at E9.5

Allelic Composition	Sox11^tm1.2Vlf/Sox11⁺ Sox4^tm1.1Vlf/Sox4⁺
Genetic Background	involves: 129 * C57BL/6 * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sox11^tm1.2Vlf mutation (0 available); any Sox11 mutation (15 available)
Sox4^tm1.1Vlf mutation (0 available); any Sox4 mutation (23 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

perinatal lethality, complete penetrance ( J:175338 )

• mice die on birth

skeleton

abnormal cranium morphology ( J:175338 )

• hypomineralized skull with wide sutures

wide cranial sutures ( J:175338 )

abnormal sternebra morphology ( J:175338 )

• hypoplastic

• the last two or three sternebrae are misshapen and irregularly mineralized

sternebra fusion ( J:175338 )

abnormal xiphoid process morphology ( J:175338 )

• the xiphoid process is misshapen and irregularly mineralized

abnormal lumbar vertebrae morphology ( J:175338 )

• unfused lumbar vertebral bodies

• L4 and L5 are duplicated

abnormal bone mineralization ( J:175338 )

• hypomineralized skull

• the last two or three sternebrae and the xiphoid process are irregularly mineralized

cardiovascular system

double outlet right ventricle ( J:175338 )

ventricular septal defect ( J:175338 )

• incomplete ventricular septation

vision/eye

vision/eye phenotype ( J:175338 )

N	• mice exhibit normal eyes

craniofacial

craniofacial phenotype ( J:175338 )

N	• mice exhibit normal palate and lip formation

abnormal cranium morphology ( J:175338 )

• hypomineralized skull with wide sutures

wide cranial sutures ( J:175338 )

hematopoietic system

small spleen ( J:175338 )

• in 60% of mice

immune system

small spleen ( J:175338 )

• in 60% of mice

growth/size/body

omphalocele ( J:175338 )

• in 50% of mice in one of 2 crosses

Allelic Composition	Sox11^tm1.2Vlf/Sox11^tm1.2Vlf Sox4^tm1.1Vlf/Sox4⁺
Genetic Background	involves: 129 * C57BL/6 * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sox11^tm1.2Vlf mutation (0 available); any Sox11 mutation (15 available)
Sox4^tm1.1Vlf mutation (0 available); any Sox4 mutation (23 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

lethality throughout fetal growth and development, complete penetrance ( J:175338 )

• mice die between E14.5 and E16.5

cardiovascular system

myocardium hypoplasia ( J:175338 )

• hypoplastic myocardium

persistent truncus arteriosus ( J:175338 )

semilunar valve hypoplasia ( J:175338 )

• hypoplastic semilunar valves

skeleton

micrognathia ( J:175338 )

• at E17.5

sternum hypoplasia ( J:175338 )

• at E17.5

abnormal skeleton development ( J:175338 )

• underdeveloped

vision/eye

aphakia ( J:175338 )

• at E17.5

abnormal eye development ( J:175338 )

• underdeveloped

microphthalmia ( J:175338 )

• at E17.5

eyelids open at birth ( J:175338 )

respiratory system

abnormal lung development ( J:175338 )

• underdeveloped

small lung ( J:175338 )

• at E17.5

craniofacial

micrognathia ( J:175338 )

• at E17.5

homeostasis/metabolism

edema ( J:175338 )

• generalized at E17.5

muscle

myocardium hypoplasia ( J:175338 )

• hypoplastic myocardium

Allelic Composition	Sox11^tm1.2Vlf/Sox11^tm1.2Vlf Sox4^tm1.1Vlf/Sox4^tm1.1Vlf
Genetic Background	involves: 129 * C57BL/6 * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sox11^tm1.2Vlf mutation (0 available); any Sox11 mutation (15 available)
Sox4^tm1.1Vlf mutation (0 available); any Sox4 mutation (23 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:175338 )

• mice die around E10.5

nervous system

abnormal neural tube morphology ( J:175338 )

• thin at E9.5

• increased cell death and decreased cell proliferation

incomplete rostral neuropore closure ( J:175338 )

• rostrally open neural tube at E9.5

wavy neural tube ( J:175338 )

• undulated neural tube at E9.5

cardiovascular system

abnormal heart development ( J:175338 )

• unfused heart primordia at E9.5

cardia bifida ( J:175338 )

• at E9.5

cellular

abnormal cell death ( J:175338 )

• at E9.5, mice exhibit increased cell death in the neural tube, branchial arches, and somites unlike in wild-type mice

decreased cell proliferation ( J:175338 )

• cell proliferation in the neural tube, branchial arches, and somites is reduced compared to in wild-type mice

craniofacial

abnormal pharyngeal arch mesenchyme morphology ( J:175338 )

• branchial arch mesenchyme is loose and small compared to in wild-type mice

embryo

abnormal pharyngeal arch mesenchyme morphology ( J:175338 )

• branchial arch mesenchyme is loose and small compared to in wild-type mice

incomplete embryo turning ( J:175338 )

• at E9.5

abnormal pharyngeal arch development ( J:175338 )

• increased cell death and decreased cell proliferation

embryonic growth arrest ( J:175338 )

• at E8.5

decreased embryo size ( J:175338 )

• at E9.5

absent limb buds ( J:175338 )

• limbs fail to bud

abnormal neural tube morphology ( J:175338 )

• thin at E9.5

• increased cell death and decreased cell proliferation

incomplete rostral neuropore closure ( J:175338 )

• rostrally open neural tube at E9.5

wavy neural tube ( J:175338 )

• undulated neural tube at E9.5

impaired somite development ( J:175338 )

• rudimentary with increased cell death and decreased cell proliferation

growth/size/body

abnormal pharyngeal arch mesenchyme morphology ( J:175338 )

• branchial arch mesenchyme is loose and small compared to in wild-type mice

decreased embryo size ( J:175338 )

• at E9.5

limbs/digits/tail

absent limb buds ( J:175338 )

• limbs fail to bud

Allelic Composition	Sox11^tm1.2Vlf/Sox11⁺ Sox12^tm1.1Vlf/Sox12^tm1.1Vlf Sox4^tm1.1Vlf/Sox4⁺
Genetic Background	involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sox11^tm1.2Vlf mutation (0 available); any Sox11 mutation (15 available)
Sox12^tm1.1Vlf mutation (0 available); any Sox12 mutation (8 available)
Sox4^tm1.1Vlf mutation (0 available); any Sox4 mutation (23 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

persistent truncus arteriosus ( J:175338 )

double outlet right ventricle ( J:175338 )

ventricular septal defect ( J:175338 )

• incomplete ventricular septation

skeleton

abnormal cranium morphology ( J:175338 )

• hypomineralized skull

abnormal sternebra morphology ( J:175338 )

• fusion and /or deletion

• split sternal bars in all mice

sternebra fusion ( J:175338 )

abnormal vertebrae morphology ( J:175338 )

• vertebral body duplication in all mice

abnormal bone mineralization ( J:175338 )

• hypomineralized skull

craniofacial

abnormal cranium morphology ( J:175338 )

• hypomineralized skull

immune system

small spleen ( J:175338 )

• in all mice

hematopoietic system

small spleen ( J:175338 )

• in all mice

Allelic Composition	Sox11^tm1.2Vlf/Sox11^tm1.2Vlf Sox12^tm1.1Vlf/Sox12^tm1.1Vlf Sox4^tm1.1Vlf/Sox4^tm1.1Vlf
Genetic Background	involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sox11^tm1.2Vlf mutation (0 available); any Sox11 mutation (15 available)
Sox12^tm1.1Vlf mutation (0 available); any Sox12 mutation (8 available)
Sox4^tm1.1Vlf mutation (0 available); any Sox4 mutation (23 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

embryo

abnormal neural tube morphology ( J:175338 )

• thin

• more severe than in Sox4^tm1.1Vlf Sox11^tm2.2Weg double homozygotes

kinked neural tube ( J:175338 )

• more severe than in Sox4^tm1.1Vlf Sox11^tm2.2Weg double homozygotes

nervous system

abnormal neural tube morphology ( J:175338 )

• thin

• more severe than in Sox4^tm1.1Vlf Sox11^tm2.2Weg double homozygotes

kinked neural tube ( J:175338 )

• more severe than in Sox4^tm1.1Vlf Sox11^tm2.2Weg double homozygotes

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