All Phenotypes Adamts5<tm2.2Lex> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Adamts5^tm2.2Lex
targeted mutation 2.2, Lexicon Genetics
MGI:5285450

Summary

1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Adamts5^tm2.2Lex/Adamts5^tm2.2Lex	B6.129S5-Adamts5^tm2.2Lex	MGI:5285451

Allelic Composition	Adamts5^tm2.2Lex/Adamts5^tm2.2Lex
Genetic Background	B6.129S5-Adamts5^tm2.2Lex

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adamts5^tm2.2Lex mutation (0 available); any Adamts5 mutation (56 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

abnormal pain threshold ( J:175366 )

• following medial meniscal destabilization, male mice do not develop mechanical allodynia unlike similarly treated wild-type mice

skeleton

decreased susceptibility to induced arthritis ( J:175366 )

• following medial meniscal destabilization, mice do not exhibit lesions unlike similarly treated wild-type mice

immune system

decreased susceptibility to induced arthritis ( J:175366 )

• following medial meniscal destabilization, mice do not exhibit lesions unlike similarly treated wild-type mice

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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