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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Htra1tm1Ybf
targeted mutation 1, Yingbin Fu
MGI:5285550
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Htra1tm1Ybf/Htra1tm1Ybf involves: C57BL/6J MGI:5285552
cx2
 		Htra1tm1Ybf/Htra1tm1Ybf
Tg(BEST1-HTRA1)#Ybf/0 		involves: C57BL/6J MGI:5285553


Genotype
MGI:5285552
hm1
Allelic
Composition		 Htra1tm1Ybf/Htra1tm1Ybf
Genetic
Background		 involves: C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Htra1tm1Ybf mutation (0 available); any Htra1 mutation (54 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
vision/eye
vision/eye phenotype ( J:175227 )
N
• retinal morphology is normal




Genotype
MGI:5285553
cx2
Allelic
Composition		 Htra1tm1Ybf/Htra1tm1Ybf
Tg(BEST1-HTRA1)#Ybf/0
Genetic
Background		 involves: C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Htra1tm1Ybf mutation (0 available); any Htra1 mutation (54 available)
Tg(BEST1-HTRA1)#Ybf mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype

Similar development of polypoidal choroidal vasculopathy in Htra1tm1Ybf/Htra1tm1Ybf Tg(BEST1-HTRA1)#Ybf/0 mice as in Tg(BEST1-HTRA1)#Ybf/0 mice

vision/eye
abnormal optic choroid morphology ( J:175227 )
• defects resembling polypoidal choroidal vasculopathy (PCV) are seen

cardiovascular system
aneurysm ( J:175227 )
• small hyperfluorescent dots consistent with microaneurysmal dilations are seen




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory