Phenotypes associated with this allele

• Allele Symbol: Stc2^tm1Gthi
• Allele Name: targeted mutation 1, Gopal Thinakaran
• Allele ID: MGI:5285561
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Stc2^tm1Gthi/Stc2^tm1Gthi	involves: 129S/SvEv * C57BL/6	MGI:5285570

Genotype
MGI:5285570

hm1

• Allelic Composition: Stc2^tm1Gthi/Stc2^tm1Gthi
• Genetic Background: involves: 129S/SvEv * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

abnormal cell physiology ( J:175075 )

• mouse embryonic fibroblasts (MEFs) exhibit altered calcium ion homeostasis (namely, store-operated calcium ion entry) compared with wild-type cells

• MEFs treated with thapsigargin exhibit increased magnesium ion influx rate following store depletion compared with similarly treated wild-type cells

• however, internal calcium ion stores in MEFs are normal

increased sensitivity to induced cell death ( J:175075 )

• in mouse embryonic fibroblasts treated with thapsigargin

increased cellular sensitivity to hydrogen peroxide ( J:175075 )

• in mouse embryonic fibroblasts

growth/size/body

increased body weight ( J:175075 )