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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		H2-Ab1b-tm1.1Koni
targeted mutation 1.1, Pandelakis A Koni
MGI:5285594
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		H2-Ab1b-tm1Koni/H2-Ab1b-tm1.1Koni
Tg(Tek-cre)12Flv/0 		involves: 129X1/SvJ * C3H * C57BL/6 * C57BL/6J MGI:5285614
cn2
 		H2-Ab1b-tm1.1Koni/H2-Ab1b-tm1.1Koni
Tg(Tek-cre)12Flv/0 		involves: 129X1/SvJ * C3H * C57BL/6 * C57BL/6J MGI:5285615


Genotype
MGI:5285614
cn1
Allelic
Composition		 H2-Ab1b-tm1Koni/H2-Ab1b-tm1.1Koni
Tg(Tek-cre)12Flv/0
Genetic
Background		 involves: 129X1/SvJ * C3H * C57BL/6 * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2-Ab1b-tm1.1Koni mutation (0 available); any H2-Ab1 mutation (83 available)
H2-Ab1b-tm1Koni mutation (2 available); any H2-Ab1 mutation (83 available)
Tg(Tek-cre)12Flv mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:131774 )
N
• T regulatory cells exhibit division in response to IL2
• CD4+CD25+ exhibit effective suppressive activity
increased CD4-positive, alpha-beta T cell number ( J:131774 )
• 1.5- to 2-fold in CD4+CD8- but not CD8-CD4+CD25+
abnormal CD4-positive, CD25-positive, alpha-beta regulatory T cell morphology ( J:131774 )
• CD4+CD25+ fopx3high T regulatory cells exhibit reduced CD25 expression compared with control cells
abnormal T cell activation ( J:131774 )
• mice exhibit a reduced number of preactivated CD4 T cells and CD4+CD25+ cells compared with wild-type mice
decreased level of surface class II molecules ( J:131774 )
• in splenic hemopoietic cells (B cells, CD8a- dendritic cells, and CD8a+ dendritic cells) and Langerhans cells

hematopoietic system
increased CD4-positive, alpha-beta T cell number ( J:131774 )
• 1.5- to 2-fold in CD4+CD8- but not CD8-CD4+CD25+
abnormal CD4-positive, CD25-positive, alpha-beta regulatory T cell morphology ( J:131774 )
• CD4+CD25+ fopx3high T regulatory cells exhibit reduced CD25 expression compared with control cells
abnormal T cell activation ( J:131774 )
• mice exhibit a reduced number of preactivated CD4 T cells and CD4+CD25+ cells compared with wild-type mice




Genotype
MGI:5285615
cn2
Allelic
Composition		 H2-Ab1b-tm1.1Koni/H2-Ab1b-tm1.1Koni
Tg(Tek-cre)12Flv/0
Genetic
Background		 involves: 129X1/SvJ * C3H * C57BL/6 * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2-Ab1b-tm1.1Koni mutation (0 available); any H2-Ab1 mutation (83 available)
Tg(Tek-cre)12Flv mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
preweaning lethality, incomplete penetrance ( J:131774 )
• fewer than expected mice are produced




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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory