Phenotypes associated with this allele

• Allele Symbol: Chrna4^tm1.1Tmcg
• Allele Name: targeted mutation 1.1, Tresa M McGranahan
• Allele ID: MGI:5285618
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Chrna4^tm1.1Tmcg/Chrna4^tm1.1Tmcg Slc6a3^tm1(cre)Xz/Slc6a3^+	involves: 129S/SvEv * 129S1/Sv * C57BL/6	MGI:5285626

Genotype
MGI:5285626

cn1

• Allelic Composition: Chrna4^tm1.1Tmcg/Chrna4^tm1.1Tmcg; Slc6a3^tm1(cre)Xz/Slc6a3⁺
• Genetic Background: involves: 129S/SvEv * 129S1/Sv * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

enhanced behavioral response to nicotine ( J:174505 )

• mice exhibit increased sensitivity to nicotine-induced locomotor depression compared with similarly treated wild-type mice

impaired behavioral response to nicotine ( J:174505 )

• mice exhibit decreased place preference associated with nicotine compared with wild-type mice

• however, place preference associated with cocaine is normal

impaired conditioned place preference behavior ( J:174505 )

• mice exhibit decreased place preference associated with nicotine compared with wild-type mice

• mice are insensitive to the anxiolytic effects of nicotine unlike wild-type mice

• however, mice exhibit normal nicotine-induced hypothermia

nervous system

abnormal synaptic dopamine release ( J:174505 )

• alpha-CtxMII-resistant dopamine release is abolished at low and moderate nicotine concentrations compared to in similarly treated wild-type neurons

• alpha-CtxMII-sensitive dopamine release is reduced at low levels of nicotine compared to in similarly treated wild-type neurons

• however, neurons exhibit normal alpha-CtxMII-sensitive dopamine release at moderate concentrations of nicotine and nicotine-stimulated GABA release from the cortex