Phenotypes associated with this allele

• Allele Symbol: Chrna4^tm1.2Tmcg
• Allele Name: targeted mutation 1.2, Tresa M McGranahan
• Allele ID: MGI:5285619
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Chrna4^tm1.2Tmcg/Chrna4^tm1.2Tmcg	involves: 129S/SvEv * 129S1/Sv * C57BL/6	MGI:5285628

Genotype
MGI:5285628

hm1

• Allelic Composition: Chrna4^tm1.2Tmcg/Chrna4^tm1.2Tmcg
• Genetic Background: involves: 129S/SvEv * 129S1/Sv * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

impaired behavioral response to nicotine ( J:174505 )

• mice exhibit decreased place preference associated with nicotine compared with wild-type mice

• mice are insensitive to the anxiolytic effects of nicotine unlike wild-type mice

• mice exhibit decreased sensitivity to locomotor depression induced by 1 mg/kg nicotine compared with similarly treated wild-type mice

• mice exhibit resistance to nicotine-induced hypothermia compared with similarly treated wild-type mice

• however, mice exhibit normal locomotor depression in response to treatment with 2 mg/kg nicotine

impaired conditioned place preference behavior ( J:174505 )

• mice exhibit decreased place preference associated with nicotine compared with wild-type mice

• however, place preference associated with cocaine is normal

nervous system

abnormal synaptic dopamine release ( J:174505 )

• alpha-CtxMII-resistant dopamine release is abolished at low and moderate nicotine concentrations compared to in similarly treated wild-type neurons

• alpha-CtxMII-sensitive dopamine release is reduced at low levels of nicotine compared to in similarly treated wild-type neurons

• however, neurons exhibit normal alpha-CtxMII-sensitive dopamine release at moderate concentrations of nicotine

decreased neurotransmitter release ( J:174505 )

• nicotine-stimulated GABA release from the striatum and cortex is eliminated compared to in similarly treated wild-type neurons