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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Lmnb2tm1.1Sgy
targeted mutation 1.1, Stephen G Young
MGI:5285673
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Lmnb1tm1.1Sgy/Lmnb1tm1.1Sgy
Lmnb2tm1.1Sgy/Lmnb2tm1.1Sgy
Tg(KRT14-cre)1Cgn/0 		involves: 129P2/OlaHsd * C57BL/6 * DBA/2 MGI:5285675
cn2
 		Lmnb2tm1.1Sgy/Lmnb2tm1.1Sgy
Tg(KRT14-cre)1Cgn/0 		involves: 129P2/OlaHsd * C57BL/6 * DBA/2 MGI:5285682


Genotype
MGI:5285675
cn1
Allelic
Composition		 Lmnb1tm1.1Sgy/Lmnb1tm1.1Sgy
Lmnb2tm1.1Sgy/Lmnb2tm1.1Sgy
Tg(KRT14-cre)1Cgn/0
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lmnb1tm1.1Sgy mutation (1 available); any Lmnb1 mutation (39 available)
Lmnb2tm1.1Sgy mutation (1 available); any Lmnb2 mutation (27 available)
Tg(KRT14-cre)1Cgn mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
mortality/aging ( J:174963 )
N
• mice are born at Mendelian frequency and survive for over 2 years

integument
integument phenotype ( J:174963 )
N
• keratinocytes exhibit normal proliferation
• mice exhibit normal skin and hair
abnormal keratinocyte morphology ( J:174963 )
• keratinocytes exhibit an increase in misshapen cell nuclei and nuclear blebs in culture compared with wild-type cells
• however, no polyploidy is observed




Genotype
MGI:5285682
cn2
Allelic
Composition		 Lmnb2tm1.1Sgy/Lmnb2tm1.1Sgy
Tg(KRT14-cre)1Cgn/0
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lmnb2tm1.1Sgy mutation (1 available); any Lmnb2 mutation (27 available)
Tg(KRT14-cre)1Cgn mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
mortality/aging ( J:174963 )
N
• mice are born at Mendelian frequency and survive for over 2 years




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory