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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Lgr5tm2.1Cle
targeted mutation 2.1, Hans Clevers
MGI:5285688
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Lgr4tm1.1Knis/Lgr4tm1.1Knis
Lgr5tm2.1Cle/Lgr5tm2.1Cle
Tg(Cyp1a1-cre)1Dwi/0 		involves: 129P2/OlaHsd * C57BL/6 * CBA MGI:5285826
cn2
 		Lgr5tm2.1Cle/Lgr5tm2.1Cle
Tg(Cyp1a1-cre)1Dwi/0 		involves: 129P2/OlaHsd * C57BL/6 * CBA MGI:5285828
cn3
 		Lgr4tm1.1Knis/Lgr4tm1.1Knis
Lgr5tm2.1Cle/Lgr5tm2.1Cle
Tg(Vil1-cre/ERT2)23Syr/0 		involves: 129P2/OlaHsd * C57BL/6 * DBA/2 MGI:5285825


Genotype
MGI:5285826
cn1
Allelic
Composition		 Lgr4tm1.1Knis/Lgr4tm1.1Knis
Lgr5tm2.1Cle/Lgr5tm2.1Cle
Tg(Cyp1a1-cre)1Dwi/0
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lgr4tm1.1Knis mutation (0 available); any Lgr4 mutation (94 available)
Lgr5tm2.1Cle mutation (0 available); any Lgr5 mutation (58 available)
Tg(Cyp1a1-cre)1Dwi mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:174842 )
• in beta-napthoflavone-treated mice

digestive/alimentary system
abnormal small intestinal crypt cell proliferation ( J:174842 )
• after 5 days, beta-napthoflavone-treated mice exhibit a loss of crypt width with loss of crypt stem cells and proliferating progenitors compared with control mice
• however, wild-type crypt stem cell escapers exhibit proliferation
decreased small intestinal villus size ( J:174842 )
• in beta-napthoflavone-treated mice

cellular
abnormal small intestinal crypt cell proliferation ( J:174842 )
• after 5 days, beta-napthoflavone-treated mice exhibit a loss of crypt width with loss of crypt stem cells and proliferating progenitors compared with control mice
• however, wild-type crypt stem cell escapers exhibit proliferation




Genotype
MGI:5285828
cn2
Allelic
Composition		 Lgr5tm2.1Cle/Lgr5tm2.1Cle
Tg(Cyp1a1-cre)1Dwi/0
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lgr5tm2.1Cle mutation (0 available); any Lgr5 mutation (58 available)
Tg(Cyp1a1-cre)1Dwi mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
digestive/alimentary system
digestive/alimentary phenotype ( J:174842 )
N
• beta-napthoflavone-treated mice exhibit normal crypt width and crypt stem cell proliferation




Genotype
MGI:5285825
cn3
Allelic
Composition		 Lgr4tm1.1Knis/Lgr4tm1.1Knis
Lgr5tm2.1Cle/Lgr5tm2.1Cle
Tg(Vil1-cre/ERT2)23Syr/0
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lgr4tm1.1Knis mutation (0 available); any Lgr4 mutation (94 available)
Lgr5tm2.1Cle mutation (0 available); any Lgr5 mutation (58 available)
Tg(Vil1-cre/ERT2)23Syr mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
digestive/alimentary system
abnormal intestine physiology ( J:174842 )
• generated intestinal organoids degrade after 2 days of tamoxifen treatment
• however, organoid survival is rescued by retroviral expression of LGR5




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory