All Phenotypes Tsix<tm1.1Awu> MGI Mouse

embryonic growth retardation ( J:174672 )

• when Tsix^tm1.1Awu is inherited paternally, female mice treated with doxycycline from E0.5 exhibit severe developmental defect at E7.5 compared with control mice

• however, no developmental defect is observed when the allele is maternally inherited or when doxycycline treated blastocysts with paternally inherited Tsix^tm1.1Awu are transplanted into wild-type recipients

abnormal placenta labyrinth morphology ( J:174672 )

• when Tsix^tm1.1Awu is inherited maternally, female mice treated with doxycycline from E6.5 exhibit reduced density of fetal capillaries in the placental labyrinth compared with control mice

• when Tsix^tm1.1Awu is inherited paternally, female mice treated with doxycycline from E6.5 exhibit a severe defect in fetal capillaries compared with control mice

absent placental labyrinth ( J:174672 )

• in severely affected female mice treated with doxycycline from E6.5 when Tsix^tm1.1Awu is inherited paternally

small placenta ( J:174672 )

• at E13.5 in female mice treated with doxycycline from E6.5 or E7.5 when Tsix^tm1.1Awu is inherited paternally

• mild at E13.5 in female mice treated with doxycycline from E8.5 when Tsix^tm1.1Awu is inherited paternally

• however, female mice treated with doxycycline from E9.5 exhibit normal placenta size at E13.5 when the allele is inherited paternally

abnormal trophoblast layer morphology ( J:174672 )

• when Tsix^tm1.1Awu is inherited paternally, female mice treated with doxycycline from E6.5 exhibit a severe defect in all trophoblast cell types compared with control mice

abnormal trophoblast giant cell morphology ( J:174672 )

• when Tsix^tm1.1Awu is inherited paternally, female mice treated with doxycycline from E6.5 exhibit overabundant and massively enlarged compared to in control mice

increased trophoblast giant cell number ( J:174672 )

• in severely affected female mice treated with doxycycline from E6.5 when Tsix^tm1.1Awu is inherited paternally

absent spongiotrophoblast ( J:174672 )

• absent in severely affected female mice treated with doxycycline from E6.5 when Tsix^tm1.1Awu is inherited paternally

abnormal DNA methylation ( J:174672 )

• increased in female mice treated with doxycycline from E6.5 when Tsix^tm1.1Awu is inherited paternally

abnormal dosage compensation, by inactivation of X chromosome ( J:174672 )

• in female mice treated with doxycycline from E6.5 when Tsix^tm1.1Awu is inherited paternally

abnormal imprinting ( J:174672 )

• when Tsix^tm1.1Awu is inherited paternally, female mice treated with doxycycline from E0.5 fail to imprint and inactivated the paternal X chromosome unlike in control mice

abnormal capillary morphology ( J:174672 )

• when Tsix^tm1.1Awu is inherited maternally, female mice treated with doxycycline from E6.5 exhibit reduced density of fetal capillaries in the placental labyrinth compared with control mice

• when Tsix^tm1.1Awu is inherited paternally, female mice treated with doxycycline from E6.5 exhibit a severe defect in fetal capillaries compared with control mice

decreased capillary density ( J:174672 )

embryonic growth retardation ( J:174672 )

• when Tsix^tm1.1Awu is inherited paternally, female mice treated with doxycycline from E0.5 exhibit severe developmental defect at E7.5 compared with control mice

• however, no developmental defect is observed when the allele is maternally inherited or when doxycycline treated blastocysts with paternally inherited Tsix^tm1.1Awu are transplanted into wild-type recipients

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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