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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Padi4tm1.1Kmow
targeted mutation 1.1, Kerri A Mowen
MGI:5285854
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Padi4tm1.1Kmow/Padi4tm1.1Kmow involves: BALB/cJ * C57BL/6 MGI:5285855
cn2
 		Padi4tm1.1Kmow/Padi4tm1.1Kmow
Tg(CMV-cre)1Cgn/0 		involves: BALB/cJ * C57BL/6 MGI:5451198


Genotype
MGI:5285855
hm1
Allelic
Composition		 Padi4tm1.1Kmow/Padi4tm1.1Kmow
Genetic
Background		 involves: BALB/cJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Padi4tm1.1Kmow mutation (2 available); any Padi4 mutation (41 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal neutrophil physiology ( J:174934 )
• neutrophils lack histone deimination unlike wild-type cells
decreased susceptibility to Orthomyxoviridae infection ( J:174934 )
• influenza-infected mice exhibit decreased weight loss compared with similarly treated wild-type mice
• however, influenza-infected mice exhibit normal survival, neutrophil recruitment into the lung, lung viral titers, and pro-inflammatory cytokine levels

growth/size/body
decreased susceptibility to weight loss ( J:174934 )
• influenza-infected mice exhibit decreased weight loss compared with similarly treated wild-type mice

hematopoietic system
abnormal neutrophil physiology ( J:174934 )
• neutrophils lack histone deimination unlike wild-type cells




Genotype
MGI:5451198
cn2
Allelic
Composition		 Padi4tm1.1Kmow/Padi4tm1.1Kmow
Tg(CMV-cre)1Cgn/0
Genetic
Background		 involves: BALB/cJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Padi4tm1.1Kmow mutation (2 available); any Padi4 mutation (41 available)
Tg(CMV-cre)1Cgn mutation (6 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:190651 )
N
• bone marrow-derived mast cells exhibit normal ATP-stimulated citrullination




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory