Phenotypes associated with this allele

• Allele Symbol: Tg(Gfap-cre)#Mvs
• Allele Name: transgene insertion, Michael V Sofroniew
• Allele ID: MGI:5285867
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Gt(ROSA)26Sor^tm1(CAG-Mir21)Jake/Gt(ROSA)26Sor^+ Tg(Gfap-cre)#Mvs/0	involves: BALB/c * C57BL/6 * C57BL/6NHsd	MGI:5474353
cn2	Gt(ROSA)26Sor^tm2Jake/Gt(ROSA)26Sor^+ Tg(Gfap-cre)#Mvs/0	involves: BALB/c * C57BL/6 * C57BL/6NHsd	MGI:5474354

Genotype
MGI:5474353

cn1

• Allelic Composition: Gt(ROSA)26Sor^{tm1(CAG-Mir21)Jake}/Gt(ROSA)26Sor⁺; Tg(Gfap-cre)#Mvs/0
• Genetic Background: involves: BALB/c * C57BL/6 * C57BL/6NHsd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

abnormal response to injury ( J:192021 )

• at 14 days post injury, astrocytes adjacent to spinal cord lesions are smaller and have thinner processes compared to astrocytes in injured wild-type mice

increased susceptibility to injury ( J:192021 )

• lesion size is increased approximately 80% compared to wild-type mice following severe spinal cord injury

nervous system

abnormal astrocyte morphology ( J:192021 )

• at 14 days post injury, astrocytes adjacent to spinal cord lesions are smaller and have thinner processes compared to astrocytes in injured wild-type mice

abnormal astrocyte physiology ( J:192021 )

• at 14 days post spinal injury formation of reactive astrocytes is reduced compared to injured wild-type controls

Genotype
MGI:5474354

cn2

• Allelic Composition: Gt(ROSA)26Sor^tm2Jake/Gt(ROSA)26Sor⁺; Tg(Gfap-cre)#Mvs/0
• Genetic Background: involves: BALB/c * C57BL/6 * C57BL/6NHsd

homeostasis/metabolism

abnormal response to injury ( J:192021 )

• at 14 days post injury, astrocytes adjacent to spinal cord lesions are larger and have thicker processes compared to astrocytes in injured wild-type mice

• however, lesion size is similar to that in injured wild-type mice

• at 35 days post injury astrocytes adjacent to the injury site remain hypertrophic unlike in wild-type controls

• increase in the number of axons present within the injury site

nervous system

abnormal astrocyte morphology ( J:192021 )

• at 14 days post injury, astrocytes adjacent to spinal cord lesions are larger and have thicker processes compared to astrocytes in injured wild-type mice

• at 35 days post injury astrocytes adjacent to the injury site remain hypertrophic unlike in wild-type controls

abnormal astrocyte physiology ( J:192021 )

• at 14 days post spinal injury formation of reactive astrocytes is increased compared to injured wild-type controls