Phenotypes associated with this allele

• Allele Symbol: Acox1^lampe1
• Allele Name: lampe1
• Allele ID: MGI:5285926
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Acox1^lampe1/Acox1^lampe1	involves: C57BL/6J	MGI:5285941

Genotype
MGI:5285941

hm1

• Allelic Composition: Acox1^lampe1/Acox1^lampe1
• Genetic Background: involves: C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

liver/biliary system

liver inflammation ( J:174942 )

• inflammatory infiltrates, comprised of numerous clusters of lymphocytes and Kupffer cells, seen accompanying partial resolution of steatosis

abnormal liver morphology ( J:174942 )

• at 15 months of age livers contain distinct nodular lesions with slightly different color from the surrounding hepatic parenchyma

• nodules, consisting of eosinophilic and/or basophilic hepatocytes with focal or diffuse dysplastic changes and increased cell density, almost completely replace the liver parenchyma

enlarged liver ( J:174942 )

• at 10 weeks and 15 months of age

abnormal hepatocyte morphology ( J:174942 )

• numerous lipid vacuoles of varying sizes are seen within the cytoplasm of zones 2 and 3 hepatocytes

• steatotic hepatocytes either lack or show diminished numbers of peroxisomes while hepatocytes immediately adjacent to fatty areas have higher amounts of peroxisomes

microvesicular hepatic steatosis ( J:174942 )

• show microvesicular steatosis involving most of the hepatic lobule with sparing of periportal hepatocytes at 8 weeks of age

• striking zonal pattern of steatosis persists at 3 and 4 months of age

• at 6 months of age, livers display areas of steatosis along with areas with complete resolution of the steatosis

• numerous lipid vacuoles of varying sizes are seen within the cytoplasm of zones 2 and 3 hepatocytes

increased hepatocellular carcinoma incidence ( J:174942 )

• occur in multiple areas intermingled with dysplastic foci at around 1 year of age

homeostasis/metabolism

increased circulating alanine transaminase level ( J:174942 )

increased circulating alkaline phosphatase level ( J:174942 )

neoplasm

increased hepatocellular carcinoma incidence ( J:174942 )

• occur in multiple areas intermingled with dysplastic foci at around 1 year of age

reproductive system

reduced fertility ( J:174942 )

growth/size/body

postnatal growth retardation ( J:174942 )

• at 6 weeks of age

enlarged liver ( J:174942 )

• at 10 weeks and 15 months of age

immune system

liver inflammation ( J:174942 )

• inflammatory infiltrates, comprised of numerous clusters of lymphocytes and Kupffer cells, seen accompanying partial resolution of steatosis