Phenotypes associated with this allele

• Allele Symbol: Nrg1^m1Yzcm
• Allele Name: mutation 1, Yangzhou University Comparative Medicine Center
• Allele ID: MGI:5285952
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Nrg1^m1Yzcm/Nrg1^m1Yzcm	C57BL/6J-Nrg1^m1Yzcm	MGI:5285958
ht2	Nrg1^m1Yzcm/Nrg1^+	C57BL/6J-Nrg1^m1Yzcm	MGI:5285957

Genotype
MGI:5285958

hm1

• Allelic Composition: Nrg1^m1Yzcm/Nrg1^m1Yzcm
• Genetic Background: C57BL/6J-Nrg1^m1Yzcm

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Dilated pupils in Nrg1^m1Yzcm/Nrg1⁺ and Nrg1^m1Yzcm/Nrg1^m1Yzcm mice

mortality/aging

preweaning lethality, incomplete penetrance ( J:175524 )

• fewer than expected mice are produced

vision/eye

abnormal iris morphology ( J:175524 )

• iris constrictor muscles exhibit reduced muscarinic 3 cholinergic receptors (ChRM3) compared to in wild-type mice

mydriasis ( J:175524 )

• 4 of 34 mice exhibit bilateral pupil dilation unlike wild-type mice

• nearly all mice exhibit complete or nearly complete bilateral pupil dilation unlike wild-type mice

Genotype
MGI:5285957

ht2

• Allelic Composition: Nrg1^m1Yzcm/Nrg1⁺
• Genetic Background: C57BL/6J-Nrg1^m1Yzcm

Dilated pupils in Nrg1^m1Yzcm/Nrg1⁺ and Nrg1^m1Yzcm/Nrg1^m1Yzcm mice

vision/eye

mydriasis ( J:175524 )

• 3 of 115 mice exhibit unilateral pupil dilation unlike wild-type mice

• 5 of 111 mice exhibit unilateral or partially dilated pupils unlike wild-type mice