Analysis Tools
homeostasis/metabolism
nuchal edema
(
J:244466
)
|
• at E18.5
|
lymphedema
(
J:244466
)
|
• at E14.5 or later, homozygotes exhibit edema formation of variable severity; some only display edema at the dorsal side while others also have edema at the ventral side
• by E18.5, all homozygotes display mild or severe edema
|
immune system
|
• at E18.5, mesenteric lymphatic vessels are significantly smaller in size, appear non-luminized, lack lymphatic valve structures, and retain higher levels of VEGFR-3, CD31, and Prox-1 expression
|
|
• at E12.5, the first lymphovenous contact site is abnormally formed: Prox-1+ cells of the cardinal vein and Prox-1+ lymphatic endothelial cells fail to come together in tight association, and no accumulation of Prox-1/Vegfr-3+ cells occurs at the lymphovenous connection site, unlike in wild-type embryos
• at E13.5, the tight association of lymphatic and venous endothelium (typical of the site of prospective valve formation) is missing, unlike in wild-type embryos
• at E18.5, mesenteric lymphatic structures fail to undergo remodeling events and show absence of lymphatic valve formation
|
integument
nuchal edema
(
J:244466
)
|
• at E18.5
|
growth/size/body
nuchal edema
(
J:244466
)
|
• at E18.5
|
