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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Arrdc4tm1(KOMP)Vlcg
targeted mutation 1, Velocigene
MGI:5286528
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Arrdc4tm1(KOMP)Vlcg/Arrdc4tm1(KOMP)Vlcg involves: C57BL/6N * C57BL/6NTac MGI:5810097


Genotype
MGI:5810097
hm1
Allelic
Composition		 Arrdc4tm1(KOMP)Vlcg/Arrdc4tm1(KOMP)Vlcg
Genetic
Background		 involves: C57BL/6N * C57BL/6NTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Arrdc4tm1(KOMP)Vlcg mutation (0 available); any Arrdc4 mutation (21 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
abnormal cell physiology ( J:236091 )
• mutant mouse embryonic fibroblasts (MEFs) show a ~30% reduction in extracellular vesicle (EV) release relative to wild-type MEFs
• in gut explants cultures, homozygotes exhibit normal levels of DMT1 (divalent metal ion transporter) released in gut EVs but show a significantly reduced protein concentration of EVs released from gut EVs relative to wild-type controls




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory