Phenotypes associated with this allele

• Allele Symbol: Syt10^{tm1.1(icre)Geno}
• Allele Name: targeted mutation 1.1, Genoway
• Allele ID: MGI:5286607
• Summary: 5 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Syt10^tm1.1(icre)Geno/Syt10^tm1.1(icre)Geno	involves: 129S2/SvPas * C57BL/6	MGI:5297478
cn2	Bmal1^tm1Weit/Bmal1^tm1Weit Syt10^tm1.1(icre)Geno/Syt10^+	involves: 129S2/SvPas * 129S4/SvJaeSor * C57BL/6	MGI:5297479
cn3	Bmal1^tm1Bra/Bmal1^tm1Weit Syt10^tm1.1(icre)Geno/Syt10^+	involves: 129S2/SvPas * 129S4/SvJaeSor * C57BL/6	MGI:5297480
cn4	Bmal1^tm1Bra/Bmal1^tm1Weit Syt10^tm1.1(icre)Geno/Syt10^tm1.1(icre)Geno	involves: 129S2/SvPas * 129S4/SvJaeSor * C57BL/6	MGI:5297485
cx5	Bmal1^tm1Bra/Bmal1^tm1Bra Syt10^tm1.1(icre)Geno/Syt10^tm1.1(icre)Geno	involves: 129S2/SvPas * 129S4/SvJaeSor * C57BL/6	MGI:5297481

Genotype
MGI:5297478

hm1

• Allelic Composition: Syt10^{tm1.1(icre)Geno}/Syt10^{tm1.1(icre)Geno}
• Genetic Background: involves: 129S2/SvPas * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:175596 )

N • circadian behavior of males is normal; mice show normal entrainment in a 12 h light, 12 h day cycle, with total activity levels and onset variability similar to wild-type

shortened circadian behavior period ( J:175596 )

• mutants have a slightly but significantly shortened period in constant light conditions compared to wild-type

advanced circadian behavior phase ( J:175596 )

• when a 15 minute light pulse is given to mice at circadian time 14 (CT14), animals exhibit a reduced phase delay of 90 minutes in contrast to wild-type and heterozygous phase delay of 140 minutes

Genotype
MGI:5297479

cn2

• Allelic Composition: Bmal1^tm1Weit/Bmal1^tm1Weit; Syt10^{tm1.1(icre)Geno}/Syt10⁺
• Genetic Background: involves: 129S2/SvPas * 129S4/SvJaeSor * C57BL/6

behavior/neurological

shortened circadian behavior period ( J:175596 )

• mice show a shortened period under constant dark conditions (DD) compared to controls; animals are still rhythmic under constant light and dark conditions, but rhythmicity under DD is less stable compared to controls (mutants show increased onset variability relative to controls)

Genotype
MGI:5297480

cn3

• Allelic Composition: Bmal1^tm1Bra/Bmal1^tm1Weit; Syt10^{tm1.1(icre)Geno}/Syt10⁺
• Genetic Background: involves: 129S2/SvPas * 129S4/SvJaeSor * C57BL/6

behavior/neurological

abnormal circadian behavior ( J:175596 )

• animals display impaired activity rhythms but are not totally arrhythmic

shortened circadian behavior period ( J:175596 )

• animals have a shorter period in constant light conditions (DD); mutants have higher onset errors than wild-type controls

Genotype
MGI:5297485

cn4

• Allelic Composition: Bmal1^tm1Bra/Bmal1^tm1Weit; Syt10^{tm1.1(icre)Geno}/Syt10^{tm1.1(icre)Geno}
• Genetic Background: involves: 129S2/SvPas * 129S4/SvJaeSor * C57BL/6

behavior/neurological

abnormal circadian behavior ( J:175596 )

• almost all animals display essentially no circadian rhythmicity (no clear circadian peak)

• under light-dark conditions (LD; 12:12 light/dark cycle), mutants are more active than wild-type in the light phase

• in animals, decreasing circadian amplitudes correlate with increasing ultradian amplitudes

Genotype
MGI:5297481

cx5

• Allelic Composition: Bmal1^tm1Bra/Bmal1^tm1Bra; Syt10^{tm1.1(icre)Geno}/Syt10^{tm1.1(icre)Geno}
• Genetic Background: involves: 129S2/SvPas * 129S4/SvJaeSor * C57BL/6

behavior/neurological

abnormal circadian behavior ( J:175596 )

• mice show no clear circadian peak

• in animals, decreasing circadian amplitudes correlate with increasing ultradian amplitudes