Analysis Tools|
Allele Symbol Allele Name Allele ID |
Hsp90aa1Tg(Tyr)2396BOve transgene lentiviral insertion 2396B, Paul A Overbeek MGI:5286686 |
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| Summary |
2 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• photoreceptor apoptosis is seen in the 6-week old retina but not at 3 weeks of age
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• Golgi apparatus is misplaced or broken/disintegrated in photoreceptors and not confined in the inner segment region and is distributed in a larger cytoplasmic area already at 3 weeks of age
• photoreceptors show aberrant intersegmental vesicle transportation
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• the connecting cilium is misplaced and less organized
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• inner segments are deteriorated with rough membrane surface and deformed shapes
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• outer segments are swollen and deformed
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• outer segment membrane discs are twisted and coiled
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• loss of photoreceptors is detected at 6 weeks of age and massive loss is seen by 15 weeks of age
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• the outer nuclear layer is thinner in 6-week old mice
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• ERG amplitudes of 3-week old mice are decreased and no ERG amplitude in response to light stimulation is seen at 20 weeks of age
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• a-wave amplitude of rod-ERG and max-ERG (combined functions of both rod and cone cells) are decreased at 3 and 20 weeks of age
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• b-wave amplitude of rod-ERG and max-ERG are decreased at 3 and 20 weeks of age
|
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• Golgi apparatus is misplaced or broken/disintegrated in photoreceptors and not confined in the inner segment region and is distributed in a larger cytoplasmic area already at 3 weeks of age
• photoreceptors show aberrant intersegmental vesicle transportation
|
|
• the connecting cilium is misplaced and less organized
|
|
• inner segments are deteriorated with rough membrane surface and deformed shapes
|
|
• outer segments are swollen and deformed
|
|
• outer segment membrane discs are twisted and coiled
|
|
• loss of photoreceptors is detected at 6 weeks of age and massive loss is seen by 15 weeks of age
|
|
• the connecting cilium is misplaced and less organized
|
|
• photoreceptor apoptosis is seen in the 6-week old retina but not at 3 weeks of age
|
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 11/19/2024 MGI 6.24 |
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