About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Ppp2r1atm1.2Wltr
targeted mutation 1.2, Gernot Walter
MGI:5287362
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Ppp2r1atm1.2Wltr/Ppp2r1atm1.2Wltr FVB.129S1-Ppp2r1atm1.2Wltr MGI:5287434
ht2
 		Ppp2r1atm1.2Wltr/Ppp2r1a+ FVB.129S1-Ppp2r1atm1.2Wltr MGI:5287437
ht3
 		Ppp2r1atm1.2Wltr/Ppp2r1atm2.1Wltr FVB.129-Ppp2r1atm1.2Wltr/Ppp2r1atm2.1Wltr MGI:5287438
cn4
 		Ppp2r1atm1.1Wltr/Ppp2r1atm1.2Wltr
Tg(CAG-cre/Esr1*)5Amc/0 		involves: 129S1/Sv * 129S4/SvJaeSor * C57BL/6 * CBA * FVB/NCrl MGI:5287435


Genotype
MGI:5287434
hm1
Allelic
Composition		 Ppp2r1atm1.2Wltr/Ppp2r1atm1.2Wltr
Genetic
Background		 FVB.129S1-Ppp2r1atm1.2Wltr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ppp2r1atm1.2Wltr mutation (0 available); any Ppp2r1a mutation (41 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
embryonic lethality, complete penetrance ( J:175748 )
• all mice die between implantation and E10.5




Genotype
MGI:5287437
ht2
Allelic
Composition		 Ppp2r1atm1.2Wltr/Ppp2r1a+
Genetic
Background		 FVB.129S1-Ppp2r1atm1.2Wltr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ppp2r1atm1.2Wltr mutation (0 available); any Ppp2r1a mutation (41 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased incidence of tumors by chemical induction ( J:175748 )
• benzopyrene-treated mice exhibit increased incidence of lung cancer compared with similarly treated wild-type mice
• however, treatment with a dominant negative Trp53 restores normal induced tumor rates
increased lung tumor incidence ( J:175748 )
• benzopyrene-treated mice exhibit increased incidence of lung cancer compared with similarly treated wild-type mice
• however, treatment with a dominant negative Trp53 restores normal induced tumor rates

homeostasis/metabolism
increased incidence of tumors by chemical induction ( J:175748 )
• benzopyrene-treated mice exhibit increased incidence of lung cancer compared with similarly treated wild-type mice
• however, treatment with a dominant negative Trp53 restores normal induced tumor rates

respiratory system
increased lung tumor incidence ( J:175748 )
• benzopyrene-treated mice exhibit increased incidence of lung cancer compared with similarly treated wild-type mice
• however, treatment with a dominant negative Trp53 restores normal induced tumor rates




Genotype
MGI:5287438
ht3
Allelic
Composition		 Ppp2r1atm1.2Wltr/Ppp2r1atm2.1Wltr
Genetic
Background		 FVB.129-Ppp2r1atm1.2Wltr/Ppp2r1atm2.1Wltr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ppp2r1atm1.2Wltr mutation (0 available); any Ppp2r1a mutation (41 available)
Ppp2r1atm2.1Wltr mutation (0 available); any Ppp2r1a mutation (41 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased incidence of tumors by chemical induction ( J:175748 )
• benzopyrene-treated mice exhibit increased incidence of lung cancer (adenomas and adenocarcinomas) compared with similarly treated wild-type mice
• however, treatment with a dominant negative Trp53 restores normal induced tumor rates
increased lung tumor incidence ( J:175748 )
• benzopyrene-treated mice exhibit increased incidence of lung cancer (adenomas and adenocarcinomas) compared with similarly treated wild-type mice
• however, treatment with a dominant negative Trp53 restores normal induced tumor rates
increased lung adenoma incidence ( J:175748 )
• in benzopyrene-treated mice
increased lung adenocarcinoma incidence ( J:175748 )
• in benzopyrene-treated mice

homeostasis/metabolism
increased incidence of tumors by chemical induction ( J:175748 )
• benzopyrene-treated mice exhibit increased incidence of lung cancer (adenomas and adenocarcinomas) compared with similarly treated wild-type mice
• however, treatment with a dominant negative Trp53 restores normal induced tumor rates

respiratory system
increased lung tumor incidence ( J:175748 )
• benzopyrene-treated mice exhibit increased incidence of lung cancer (adenomas and adenocarcinomas) compared with similarly treated wild-type mice
• however, treatment with a dominant negative Trp53 restores normal induced tumor rates
increased lung adenoma incidence ( J:175748 )
• in benzopyrene-treated mice
increased lung adenocarcinoma incidence ( J:175748 )
• in benzopyrene-treated mice




Genotype
MGI:5287435
cn4
Allelic
Composition		 Ppp2r1atm1.1Wltr/Ppp2r1atm1.2Wltr
Tg(CAG-cre/Esr1*)5Amc/0
Genetic
Background		 involves: 129S1/Sv * 129S4/SvJaeSor * C57BL/6 * CBA * FVB/NCrl
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ppp2r1atm1.1Wltr mutation (1 available); any Ppp2r1a mutation (41 available)
Ppp2r1atm1.2Wltr mutation (0 available); any Ppp2r1a mutation (41 available)
Tg(CAG-cre/Esr1*)5Amc mutation (10 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:175748 )
• mice die 6 days after tamoxifen treatment

behavior/neurological
ataxia ( J:175748 )
• tamoxifen-treated mice exhibit difficulty walking compared with control mice
hunched posture ( J:175748 )
• in tamoxifen-treated mice

growth/size/body
weight loss ( J:175748 )
• in tamoxifen-treated mice beyond the initial drop associated with tamoxifen treatment alone




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
12/17/2024
MGI 6.24 		The Jackson Laboratory