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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Ppp2r1atm1.2Wltr
targeted mutation 1.2, Gernot Walter
MGI:5287362
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Ppp2r1atm1.2Wltr/Ppp2r1atm1.2Wltr FVB.129S1-Ppp2r1atm1.2Wltr MGI:5287434
ht2
 		Ppp2r1atm1.2Wltr/Ppp2r1a+ FVB.129S1-Ppp2r1atm1.2Wltr MGI:5287437
ht3
 		Ppp2r1atm1.2Wltr/Ppp2r1atm2.1Wltr FVB.129-Ppp2r1atm1.2Wltr/Ppp2r1atm2.1Wltr MGI:5287438
cn4
 		Ppp2r1atm1.1Wltr/Ppp2r1atm1.2Wltr
Tg(CAG-cre/Esr1*)5Amc/0 		involves: 129S1/Sv * 129S4/SvJaeSor * C57BL/6 * CBA * FVB/NCrl MGI:5287435


Genotype
MGI:5287434
hm1
Allelic
Composition		 Ppp2r1atm1.2Wltr/Ppp2r1atm1.2Wltr
Genetic
Background		 FVB.129S1-Ppp2r1atm1.2Wltr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ppp2r1atm1.2Wltr mutation (0 available); any Ppp2r1a mutation (41 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
embryonic lethality, complete penetrance ( J:175748 )
• all mice die between implantation and E10.5




Genotype
MGI:5287437
ht2
Allelic
Composition		 Ppp2r1atm1.2Wltr/Ppp2r1a+
Genetic
Background		 FVB.129S1-Ppp2r1atm1.2Wltr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ppp2r1atm1.2Wltr mutation (0 available); any Ppp2r1a mutation (41 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased incidence of tumors by chemical induction ( J:175748 )
• benzopyrene-treated mice exhibit increased incidence of lung cancer compared with similarly treated wild-type mice
• however, treatment with a dominant negative Trp53 restores normal induced tumor rates
increased lung tumor incidence ( J:175748 )
• benzopyrene-treated mice exhibit increased incidence of lung cancer compared with similarly treated wild-type mice
• however, treatment with a dominant negative Trp53 restores normal induced tumor rates

homeostasis/metabolism
increased incidence of tumors by chemical induction ( J:175748 )
• benzopyrene-treated mice exhibit increased incidence of lung cancer compared with similarly treated wild-type mice
• however, treatment with a dominant negative Trp53 restores normal induced tumor rates

respiratory system
increased lung tumor incidence ( J:175748 )
• benzopyrene-treated mice exhibit increased incidence of lung cancer compared with similarly treated wild-type mice
• however, treatment with a dominant negative Trp53 restores normal induced tumor rates




Genotype
MGI:5287438
ht3
Allelic
Composition		 Ppp2r1atm1.2Wltr/Ppp2r1atm2.1Wltr
Genetic
Background		 FVB.129-Ppp2r1atm1.2Wltr/Ppp2r1atm2.1Wltr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ppp2r1atm1.2Wltr mutation (0 available); any Ppp2r1a mutation (41 available)
Ppp2r1atm2.1Wltr mutation (0 available); any Ppp2r1a mutation (41 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased incidence of tumors by chemical induction ( J:175748 )
• benzopyrene-treated mice exhibit increased incidence of lung cancer (adenomas and adenocarcinomas) compared with similarly treated wild-type mice
• however, treatment with a dominant negative Trp53 restores normal induced tumor rates
increased lung tumor incidence ( J:175748 )
• benzopyrene-treated mice exhibit increased incidence of lung cancer (adenomas and adenocarcinomas) compared with similarly treated wild-type mice
• however, treatment with a dominant negative Trp53 restores normal induced tumor rates
increased lung adenoma incidence ( J:175748 )
• in benzopyrene-treated mice
increased lung adenocarcinoma incidence ( J:175748 )
• in benzopyrene-treated mice

homeostasis/metabolism
increased incidence of tumors by chemical induction ( J:175748 )
• benzopyrene-treated mice exhibit increased incidence of lung cancer (adenomas and adenocarcinomas) compared with similarly treated wild-type mice
• however, treatment with a dominant negative Trp53 restores normal induced tumor rates

respiratory system
increased lung tumor incidence ( J:175748 )
• benzopyrene-treated mice exhibit increased incidence of lung cancer (adenomas and adenocarcinomas) compared with similarly treated wild-type mice
• however, treatment with a dominant negative Trp53 restores normal induced tumor rates
increased lung adenoma incidence ( J:175748 )
• in benzopyrene-treated mice
increased lung adenocarcinoma incidence ( J:175748 )
• in benzopyrene-treated mice




Genotype
MGI:5287435
cn4
Allelic
Composition		 Ppp2r1atm1.1Wltr/Ppp2r1atm1.2Wltr
Tg(CAG-cre/Esr1*)5Amc/0
Genetic
Background		 involves: 129S1/Sv * 129S4/SvJaeSor * C57BL/6 * CBA * FVB/NCrl
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ppp2r1atm1.1Wltr mutation (1 available); any Ppp2r1a mutation (41 available)
Ppp2r1atm1.2Wltr mutation (0 available); any Ppp2r1a mutation (41 available)
Tg(CAG-cre/Esr1*)5Amc mutation (10 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:175748 )
• mice die 6 days after tamoxifen treatment

behavior/neurological
ataxia ( J:175748 )
• tamoxifen-treated mice exhibit difficulty walking compared with control mice
hunched posture ( J:175748 )
• in tamoxifen-treated mice

growth/size/body
weight loss ( J:175748 )
• in tamoxifen-treated mice beyond the initial drop associated with tamoxifen treatment alone




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory