About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Ppp2r1atm2.1Wltr
targeted mutation 2.1, Gernot Walter
MGI:5287375
Summary 3 genotypes


Genotype
MGI:5287440
hm1
Allelic
Composition		 Ppp2r1atm2.1Wltr/Ppp2r1atm2.1Wltr
Genetic
Background		 FVB.129-Ppp2r1atm2.1Wltr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ppp2r1atm2.1Wltr mutation (0 available); any Ppp2r1a mutation (41 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:175748 )
• mice are viable




Genotype
MGI:5287436
ht2
Allelic
Composition		 Ppp2r1atm2.1Wltr/Ppp2r1a+
Genetic
Background		 FVB.129-Ppp2r1atm2.1Wltr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ppp2r1atm2.1Wltr mutation (0 available); any Ppp2r1a mutation (41 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased incidence of tumors by chemical induction ( J:175748 )
• benzopyrene-treated mice exhibit increased incidence of lung cancer compared with similarly treated wild-type mice
• however, treatment with a dominant negative Trp53 restores normal induced tumor rates
increased lung tumor incidence ( J:175748 )
• benzopyrene-treated mice exhibit increased incidence of lung cancer compared with similarly treated wild-type mice
• however, treatment with a dominant negative Trp53 restores normal induced tumor rates

homeostasis/metabolism
increased incidence of tumors by chemical induction ( J:175748 )
• benzopyrene-treated mice exhibit increased incidence of lung cancer compared with similarly treated wild-type mice
• however, treatment with a dominant negative Trp53 restores normal induced tumor rates

respiratory system
increased lung tumor incidence ( J:175748 )
• benzopyrene-treated mice exhibit increased incidence of lung cancer compared with similarly treated wild-type mice
• however, treatment with a dominant negative Trp53 restores normal induced tumor rates




Genotype
MGI:5287438
ht3
Allelic
Composition		 Ppp2r1atm1.2Wltr/Ppp2r1atm2.1Wltr
Genetic
Background		 FVB.129-Ppp2r1atm1.2Wltr/Ppp2r1atm2.1Wltr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ppp2r1atm1.2Wltr mutation (0 available); any Ppp2r1a mutation (41 available)
Ppp2r1atm2.1Wltr mutation (0 available); any Ppp2r1a mutation (41 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased incidence of tumors by chemical induction ( J:175748 )
• benzopyrene-treated mice exhibit increased incidence of lung cancer (adenomas and adenocarcinomas) compared with similarly treated wild-type mice
• however, treatment with a dominant negative Trp53 restores normal induced tumor rates
increased lung tumor incidence ( J:175748 )
• benzopyrene-treated mice exhibit increased incidence of lung cancer (adenomas and adenocarcinomas) compared with similarly treated wild-type mice
• however, treatment with a dominant negative Trp53 restores normal induced tumor rates
increased lung adenoma incidence ( J:175748 )
• in benzopyrene-treated mice
increased lung adenocarcinoma incidence ( J:175748 )
• in benzopyrene-treated mice

homeostasis/metabolism
increased incidence of tumors by chemical induction ( J:175748 )
• benzopyrene-treated mice exhibit increased incidence of lung cancer (adenomas and adenocarcinomas) compared with similarly treated wild-type mice
• however, treatment with a dominant negative Trp53 restores normal induced tumor rates

respiratory system
increased lung tumor incidence ( J:175748 )
• benzopyrene-treated mice exhibit increased incidence of lung cancer (adenomas and adenocarcinomas) compared with similarly treated wild-type mice
• however, treatment with a dominant negative Trp53 restores normal induced tumor rates
increased lung adenoma incidence ( J:175748 )
• in benzopyrene-treated mice
increased lung adenocarcinoma incidence ( J:175748 )
• in benzopyrene-treated mice




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory