Phenotypes associated with this allele

• Allele Symbol: 2700049A03Rik^tm1.2Arte
• Allele Name: targeted mutation 1.2, TaconicArtemis
• Allele ID: MGI:5287585
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	2700049A03Rik^tm1.2Arte/2700049A03Rik^tm1.2Arte	either: (involves: C57BL/6NTac) or (involves: C57BL/6NTac * CD-1)	MGI:5287589

Genotype
MGI:5287589

hm1

• Allelic Composition: 2700049A03Rik^tm1.2Arte/2700049A03Rik^tm1.2Arte
• Genetic Background: either: (involves: C57BL/6NTac) or (involves: C57BL/6NTac * CD-1)

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:175541 )

• survive until E10.5

embryo

absent embryonic cilia ( J:175541 )

abnormal left-right axis patterning ( J:175541 )

• randomized

embryonic growth arrest ( J:175541 )

• Background Sensitivity: fail to develop significantly beyond E9.5 on a C57BL/6 background but develop until E10.5 on a mixed CD-1 and C57BL/6 background

abnormal neural tube morphology ( J:175541 )

• dorsalized

• neural tube cells lack cilia projecting from centrosomes and centrosomes fail to dock with the apical cell membrane

cardiovascular system

abnormal direction of heart looping ( J:175541 )

• randomized

pericardial edema ( J:175541 )

hemorrhage ( J:175541 )

• significant hemorrhaging is seen at E10.5

craniofacial

abnormal lateral nasal prominence morphology ( J:175541 )

• fused medial and lateral nasal processes creating a frontal process and nasal pit across the midline

abnormal medial nasal prominence morphology ( J:175541 )

• fused medial and lateral nasal processes creating a frontal process and nasal pit across the midline

narrow head ( J:175541 )

homeostasis/metabolism

pericardial edema ( J:175541 )

nervous system

abnormal neural tube morphology ( J:175541 )

• dorsalized

• neural tube cells lack cilia projecting from centrosomes and centrosomes fail to dock with the apical cell membrane

cellular

absent embryonic cilia ( J:175541 )

abnormal centrosome morphology ( J:175541 )

• neural tube cells lack cilia projecting from centrosomes and centrosomes fail to dock with the apical cell membrane

growth/size/body

narrow head ( J:175541 )