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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Btnl1tm1(KOMP)Mbp
targeted mutation 1, Mouse Biology Program, UC Davis
MGI:5287743
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Btnl1tm1(KOMP)Mbp/Btnl1tm1(KOMP)Mbp C57BL/6N-Btnl1tm1(KOMP)Mbp MGI:6446216
cx2
 		Btnl1tm1(KOMP)Mbp/Btnl1tm1(KOMP)Mbp
Gt(ROSA)26Sortm1(rtTA*M2)Jae/0
Tg(tetO-Btnl1)#Ahay/0 		involves: 129S4/SvJae * C57BL/6 * C57BL/6N MGI:6446222
cx3
 		Btnl1tm1(KOMP)Mbp/Btnl1tm1(KOMP)Mbp
Foxn1nu/Foxn1nu 		involves: albino stock * C57BL/6N MGI:6446219
cx4
 		Btnl1tm1(KOMP)Mbp/Btnl1tm1(KOMP)Mbp
Tg(tetO-Btnl1)#Ahay/0
Tg(Vil-rtTA2*M2)1Rsmi/0 		involves: C57BL/6N * FVB/N MGI:6446221


Genotype
MGI:6446216
hm1
Allelic
Composition		 Btnl1tm1(KOMP)Mbp/Btnl1tm1(KOMP)Mbp
Genetic
Background		 C57BL/6N-Btnl1tm1(KOMP)Mbp
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Btnl1tm1(KOMP)Mbp mutation (2 available); any Btnl1 mutation (30 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
decreased gamma-delta intraepithelial T cell number ( J:236526 )
• 90% loss of TCRVgamma7+ intraepithelial lymphocytes (IELs) in the gut
• almost total loss of TCRVgamma7GL2+ IELs in the gut
• Normal TCRVgamma7- IEL number in the gut
abnormal CD8 positive, alpha-beta intraepithelial T cell morphology ( J:236526 )
• significantly increased TCRbeta+ CD8alpha+ intraepithelial lymphocyte (IEL) level in the gut

immune system
decreased gamma-delta intraepithelial T cell number ( J:236526 )
• 90% loss of TCRVgamma7+ intraepithelial lymphocytes (IELs) in the gut
• almost total loss of TCRVgamma7GL2+ IELs in the gut
• Normal TCRVgamma7- IEL number in the gut
abnormal CD8 positive, alpha-beta intraepithelial T cell morphology ( J:236526 )
• significantly increased TCRbeta+ CD8alpha+ intraepithelial lymphocyte (IEL) level in the gut




Genotype
MGI:6446222
cx2
Allelic
Composition		 Btnl1tm1(KOMP)Mbp/Btnl1tm1(KOMP)Mbp
Gt(ROSA)26Sortm1(rtTA*M2)Jae/0
Tg(tetO-Btnl1)#Ahay/0
Genetic
Background		 involves: 129S4/SvJae * C57BL/6 * C57BL/6N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Btnl1tm1(KOMP)Mbp mutation (2 available); any Btnl1 mutation (30 available)
Gt(ROSA)26Sortm1(rtTA*M2)Jae mutation (30 available); any Gt(ROSA)26Sor mutation (993 available)
Tg(tetO-Btnl1)#Ahay mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
decreased gamma-delta intraepithelial T cell number ( J:236526 )
• 90% loss of TCRVgamma7+ intraepithelial lymphocytes (IELs) in the gut with or without doxycycline administration
• almost total loss of TCRVgamma7GL2+ IELs in the gut with or without doxycycline administration
• normal CD122hi TCRVgamma7+ IELs (most also Ki67+) in the gut after doxycycline administration

immune system
decreased gamma-delta intraepithelial T cell number ( J:236526 )
• 90% loss of TCRVgamma7+ intraepithelial lymphocytes (IELs) in the gut with or without doxycycline administration
• almost total loss of TCRVgamma7GL2+ IELs in the gut with or without doxycycline administration
• normal CD122hi TCRVgamma7+ IELs (most also Ki67+) in the gut after doxycycline administration




Genotype
MGI:6446219
cx3
Allelic
Composition		 Btnl1tm1(KOMP)Mbp/Btnl1tm1(KOMP)Mbp
Foxn1nu/Foxn1nu
Genetic
Background		 involves: albino stock * C57BL/6N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Btnl1tm1(KOMP)Mbp mutation (2 available); any Btnl1 mutation (30 available)
Foxn1nu mutation (43 available); any Foxn1 mutation (106 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
decreased gamma-delta intraepithelial T cell number ( J:236526 )
• 90% loss of TCRVgamma7+ intraepithelial lymphocytes (IELs) in the gut
• almost total loss of TCRVgamma7GL2+ IELs in the gut

immune system
decreased gamma-delta intraepithelial T cell number ( J:236526 )
• 90% loss of TCRVgamma7+ intraepithelial lymphocytes (IELs) in the gut
• almost total loss of TCRVgamma7GL2+ IELs in the gut




Genotype
MGI:6446221
cx4
Allelic
Composition		 Btnl1tm1(KOMP)Mbp/Btnl1tm1(KOMP)Mbp
Tg(tetO-Btnl1)#Ahay/0
Tg(Vil-rtTA2*M2)1Rsmi/0
Genetic
Background		 involves: C57BL/6N * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Btnl1tm1(KOMP)Mbp mutation (2 available); any Btnl1 mutation (30 available)
Tg(tetO-Btnl1)#Ahay mutation (0 available)
Tg(Vil-rtTA2*M2)1Rsmi mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
decreased gamma-delta intraepithelial T cell number ( J:236526 )
• 90% loss of TCRVgamma7+ intraepithelial lymphocytes (IELs) in the gut with or without doxycycline administration from age 11 weeks
• almost total loss of TCRVgamma7GL2+ IELs in the gut with or without doxycycline administration from age 11 weeks
• normal CD122hi Lag3hi Thy1- TCRVgamma7+ IELs (most also Ki67+) in the gut after doxycycline administration from age 11 weeks
• normal TCRVgamma7+ and TCRVgamma7GL2+ IEL cell numbers in the gut after doxycycline administration from age 5 or 21 days

immune system
decreased gamma-delta intraepithelial T cell number ( J:236526 )
• 90% loss of TCRVgamma7+ intraepithelial lymphocytes (IELs) in the gut with or without doxycycline administration from age 11 weeks
• almost total loss of TCRVgamma7GL2+ IELs in the gut with or without doxycycline administration from age 11 weeks
• normal CD122hi Lag3hi Thy1- TCRVgamma7+ IELs (most also Ki67+) in the gut after doxycycline administration from age 11 weeks
• normal TCRVgamma7+ and TCRVgamma7GL2+ IEL cell numbers in the gut after doxycycline administration from age 5 or 21 days




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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11/05/2024
MGI 6.24 		The Jackson Laboratory