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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tg(Tpbpa-cre,-EGFP)5Jcc
transgene insertion 5, James C Cross
MGI:5287872
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Notch2tm3Grid/Notch2tm3Grid
Tg(Tpbpa-cre,-EGFP)5Jcc/0 		involves: 129S1/Sv MGI:5288006
cn2
 		Rr27tm1Kpfe/Rr27+
Tg(Tpbpa-cre,-EGFP)5Jcc/0 		involves: 129S1/Sv * 129X1/SvJ MGI:7287525
cn3
 		E2f7tm1Gle/E2f7tm1Gle
E2f8tm1Gle/E2f8tm1Gle
Tg(Tpbpa-cre,-EGFP)5Jcc/0 		involves: 129S6/SvEvTac MGI:5473263


Genotype
MGI:5288006
cn1
Allelic
Composition		 Notch2tm3Grid/Notch2tm3Grid
Tg(Tpbpa-cre,-EGFP)5Jcc/0
Genetic
Background		 involves: 129S1/Sv
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Notch2tm3Grid mutation (2 available); any Notch2 mutation (99 available)
Tg(Tpbpa-cre,-EGFP)5Jcc mutation (4 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
abnormal placenta vasculature ( J:173527 )
• trophoblast giant cells and glycogen trophoblast cells fail to invade maternal spiral arterioles at E12.5 indicating a failure of endovascular invasion
• trophoblast-lined canals in the placenta that transport maternal blood to the labyrinth are reduced in size by 30-40%
• placentas fail to remodel maternal blood vessels adequately resulting in reduced placental perfusion by about 23% in mutants

embryo
abnormal placenta vasculature ( J:173527 )
• trophoblast giant cells and glycogen trophoblast cells fail to invade maternal spiral arterioles at E12.5 indicating a failure of endovascular invasion
• trophoblast-lined canals in the placenta that transport maternal blood to the labyrinth are reduced in size by 30-40%
• placentas fail to remodel maternal blood vessels adequately resulting in reduced placental perfusion by about 23% in mutants

endocrine/exocrine glands
abnormal ovary morphology ( J:173527 )
• females exhibit severe ovarian defects

reproductive system
abnormal ovary morphology ( J:173527 )
• females exhibit severe ovarian defects
abnormal pregnancy ( J:173527 )
• homozygous mothers mated with homozygous males exhibit a loss of embryos as early as E9.5, with 54% resorption between E11.5 and E14.5
• homozygous mothers mated with heterozygous males and heterozygous mothers mated with homozygous males exhibit a similar loss of both heterozygous and homozygous embryos, indicating that lethality is not due to maternal factors and is correlated with the presence of homozygous embryos rather than the genotype of individual embryos
• homozygous mothers have fewer implantation sites than controls

growth/size/body
ovarian follicular cyst ( J:173527 )

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
pre-eclampsia DOID:10591 OMIM:189800
OMIM:609402
OMIM:609403
OMIM:609404
OMIM:614592
 J:173527




Genotype
MGI:7287525
cn2
Allelic
Composition		 Rr27tm1Kpfe/Rr27+
Tg(Tpbpa-cre,-EGFP)5Jcc/0
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rr27tm1Kpfe mutation (1 available); any Rr27 mutation (7 available)
Tg(Tpbpa-cre,-EGFP)5Jcc mutation (4 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
embryo
embryo phenotype ( J:325552 )
N
• normal fetal and placental weight
• born at expected Mendelian ratios
abnormal trophoblast giant cell morphology ( J:325552 )
• 96% volume increase of trophoblast giant cells (TGC) in females
abnormal placenta junctional zone morphology ( J:325552 , J:325552 , J:325552 )
• 3x increase in cell proliferation (J:325552)
• normal apoptosis (J:325552)
• 43% volume increase in females (J:325552)
• 51% volume increase of glycogen cells (GC), 33% of spongiotrophoblasts (SpT) and 96% of trophoblast giant cells (TGC) in females (J:325552)
• 63% increase in number of glycogen cells (GC) in females (J:325552)
• normal distribution and size of glycogen cells (GC) and and spongiotrophoblasts (SpT) in females (J:325552)
• 20% volume increase in males (J:325552)
• 22% spongiotrophoblast (SpT) volume increase in males (J:325552)
• normal distribution and size of spongiotrophoblasts (SpT) and distribution, number and size of glycogen cells (GC) in males (J:325552)
increased spongiotrophoblast cell number ( J:325552 , J:325552 )
• 44% increase in spongiotrophoblast cell number in females (J:325552)
• 34% increase in spongiotrophoblast cell number in males (J:325552)

reproductive system

growth/size/body
growth/size/body region phenotype ( J:325552 )
N
• normal fetal and placental weight




Genotype
MGI:5473263
cn3
Allelic
Composition		 E2f7tm1Gle/E2f7tm1Gle
E2f8tm1Gle/E2f8tm1Gle
Tg(Tpbpa-cre,-EGFP)5Jcc/0
Genetic
Background		 involves: 129S6/SvEvTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
E2f7tm1Gle mutation (0 available); any E2f7 mutation (32 available)
E2f8tm1Gle mutation (0 available); any E2f8 mutation (35 available)
Tg(Tpbpa-cre,-EGFP)5Jcc mutation (4 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype




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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory