Phenotypes associated with this allele

• Allele Symbol: Clic4^tm1.1Aidi
• Allele Name: targeted mutation 1.1, Aihao Ding
• Allele ID: MGI:5288435
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Clic4^tm1.1Aidi/Clic4^tm1.1Aidi	involves: C57BL/6 * C57BL/6J	MGI:5288475

Genotype
MGI:5288475

hm1

• Allelic Composition: Clic4^tm1.1Aidi/Clic4^tm1.1Aidi
• Genetic Background: involves: C57BL/6 * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

decreased susceptibility to induced morbidity/mortality ( J:175404 )

• in LPS-treated mice

immune system

decreased circulating interleukin-6 level ( J:175404 )

• in LPS-treated mice

decreased circulating tumor necrosis factor level ( J:175404 )

• in LPS-treated mice

abnormal chemokine secretion ( J:175404 )

• LPS-stimulated bone marrow-derived macrophage exhibit decreased CCL5 production comapred with similarly treated wild-type cells

• LPS-treated mice exhibit decreased circulating CCL5 compared with similarly treated wild-type mice

decreased interleukin-12 secretion ( J:175404 )

• in LPS-stimulated bone marrow-derived macrophage

• in Listeria-exposed macrophages

decreased interleukin-6 secretion ( J:175404 )

• in LPS-stimulated bone marrow-derived macrophage

• in Listeria-exposed macrophages

decreased tumor necrosis factor secretion ( J:175404 )

• in bone marrow-derived macrophage stimulated with LPS or other microbial products

• in Listeria-exposed macrophages

decreased susceptibility to endotoxin shock ( J:175404 )

• LPS-treated mice exhibit improved survival with increased TNF, IL6, and CCL5 serum levels compared with similarly treated wild-type mice

increased susceptibility to bacterial infection ( J:175404 )

• mice exposed to Listeria monocytogenes exhibit increased liver burden compared with similarly treated wild-type mice

homeostasis/metabolism

decreased circulating interleukin-6 level ( J:175404 )

• in LPS-treated mice

decreased circulating tumor necrosis factor level ( J:175404 )

• in LPS-treated mice

growth/size/body

decreased body weight ( J:175404 )

• slight in young mice