All Phenotypes Mapk14<tm3.1(Mapk11)Nbr> MGI Mouse

About Help FAQ

Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Mapk14^{tm3.1(Mapk11)Nbr}
targeted mutation 3.1, Angel R Nebreda
MGI:5288509

Summary

3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Mapk14^{tm3.1(Mapk11)Nbr}/Mapk14^{tm3.1(Mapk11)Nbr}	Not Specified	MGI:5288514
cn2	Mapk11^tm1Jsca/Mapk11^tm1Jsca Mapk14^tm2Nbr/Mapk14^{tm3.1(Mapk11)Nbr} Edil3^{Tg(Sox2-cre)1Amc}/Edil3⁺	involves: 129P2/OlaHsd * C57BL/6 * CBA	MGI:5288513
cn3	Mapk14^tm2Nbr/Mapk14^{tm3.1(Mapk11)Nbr} Edil3^{Tg(Sox2-cre)1Amc}/Edil3⁺	involves: C57BL/6 * CBA	MGI:5288515

Allelic Composition	Mapk14^{tm3.1(Mapk11)Nbr}/Mapk14^{tm3.1(Mapk11)Nbr}
Genetic Background	Not Specified

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mapk14^{tm3.1(Mapk11)Nbr} mutation (0 available); any Mapk14 mutation (43 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Growth retardation and placenta abnormalities in Mapk14^{tm3.1(Mapk11)Nbr}/Mapk14^{tm3.1(Mapk11)Nbr} embryos

mortality/aging

prenatal lethality, complete penetrance ( J:176023 )

• none are found alive at birth

embryo

embryonic growth retardation ( J:176023 )

• at E11.5

decreased placental labyrinth size ( J:176023 )

• reduced in size at E11.5

abnormal trophoblast layer morphology ( J:176023 )

• thicker at E11.5

growth/size/body

embryonic growth retardation ( J:176023 )

• at E11.5

Allelic Composition	Mapk11^tm1Jsca/Mapk11^tm1Jsca Mapk14^tm2Nbr/Mapk14^{tm3.1(Mapk11)Nbr} Edil3^{Tg(Sox2-cre)1Amc}/Edil3⁺
Genetic Background	involves: 129P2/OlaHsd * C57BL/6 * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Edil3^{Tg(Sox2-cre)1Amc} mutation (5 available); any Edil3 mutation (43 available)
Mapk11^tm1Jsca mutation (0 available); any Mapk11 mutation (35 available)
Mapk14^tm2Nbr mutation (2 available); any Mapk14 mutation (43 available)
Mapk14^{tm3.1(Mapk11)Nbr} mutation (0 available); any Mapk14 mutation (43 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Cardiac defects in Mapk14^{tm3.1(Mapk11)Nbr}/Mapk14^tm2Nbr Edil3^{Tg(Sox2-cre)1Amc}/0 Mapk11^tm1Jsca/Mapk11^tm1Jsca embryos

mortality/aging

postnatal lethality, complete penetrance ( J:176023 )

• present in the expected numbers at E18.5 but none are found at weaning

cardiovascular system

ventricular septal defect ( J:176023 )

nervous system

nervous system phenotype ( J:176023 )

N	• spina bifida phenotype seen in double null mice is rescued in mice carrying the Mapk14^{tm3.1(Mapk11)Nbr} allele

Allelic Composition	Mapk14^tm2Nbr/Mapk14^{tm3.1(Mapk11)Nbr} Edil3^{Tg(Sox2-cre)1Amc}/Edil3⁺
Genetic Background	involves: C57BL/6 * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Edil3^{Tg(Sox2-cre)1Amc} mutation (5 available); any Edil3 mutation (43 available)
Mapk14^tm2Nbr mutation (2 available); any Mapk14 mutation (43 available)
Mapk14^{tm3.1(Mapk11)Nbr} mutation (0 available); any Mapk14 mutation (43 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

postnatal lethality, incomplete penetrance ( J:176023 )

• about 30% of mice survive to adulthood

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24