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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Slc6a19tm1Dgen
targeted mutation 1, Deltagen
MGI:5288516
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Slc6a19tm1Dgen/Slc6a19tm1Dgen B6.129-Slc6a19tm1Dgen MGI:5289694
hm2
 		Slc6a19tm1Dgen/Slc6a19tm1Dgen involves: 129 * C57BL/6J MGI:5289692
ht3
 		Slc6a19tm1Dgen/Slc6a19+ involves: 129 * C57BL/6J MGI:5289693


Genotype
MGI:5289694
hm1
Allelic
Composition		 Slc6a19tm1Dgen/Slc6a19tm1Dgen
Genetic
Background		 B6.129-Slc6a19tm1Dgen
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Slc6a19tm1Dgen mutation (0 available); any Slc6a19 mutation (44 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
growth/size/body
decreased body weight ( J:175382 )




Genotype
MGI:5289692
hm2
Allelic
Composition		 Slc6a19tm1Dgen/Slc6a19tm1Dgen
Genetic
Background		 involves: 129 * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Slc6a19tm1Dgen mutation (0 available); any Slc6a19 mutation (44 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype

Decreased body weight in Slc6a19tm1Dgen mice

growth/size/body
decreased lean body mass ( J:175382 )
• when fed a low protein diet
decreased body size ( J:175382 )
decreased body weight ( J:175382 )
• by 12 weeks of age
weight loss ( J:175382 )
• when fed a low or high protein diet

digestive/alimentary system
digestive/alimentary phenotype ( J:175382 )
N
• mice exhibit normal intestine morphology
abnormal intestine physiology ( J:175382 )
• mice exhibit decreased sodium-dependent leucine uptake in sections of inverted intestine compared to in wild-type mice

homeostasis/metabolism
aminoaciduria ( J:175382 )
• alanine, asparagine, glycine, glutamine, isoleucine, methionine, phenylalanine, serine, threonine, and tyrosine are increased in the urine compared to in wild-type mice
decreased circulating insulin level ( J:175382 )
• upon refeeding after fasting
insulin resistance ( J:175382 )
• mice exhibit a blunted plasma insulin response to feeding-fasting cycle compared with wild-type mice

renal/urinary system
aminoaciduria ( J:175382 )
• alanine, asparagine, glycine, glutamine, isoleucine, methionine, phenylalanine, serine, threonine, and tyrosine are increased in the urine compared to in wild-type mice
abnormal renal transport ( J:175382 )
• renal brush-border membrane vesicles (BBMVs) fail to exhibit sodium-dependent leucine uptake compared with wild-type cells
• renal BBMVs exhibit reduced sodium dependent glutamine, histidine, tryptophan, glucose, and carosine compared with wild-type cells
• renal BBMVs exhibit increased sodium-independent glutamine uptake compared with wild-type cells

adipose tissue
decreased total body fat amount ( J:175382 )
• when fed a high protein diet

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
Hartnup disease DOID:1060 OMIM:234500
 J:175382




Genotype
MGI:5289693
ht3
Allelic
Composition		 Slc6a19tm1Dgen/Slc6a19+
Genetic
Background		 involves: 129 * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Slc6a19tm1Dgen mutation (0 available); any Slc6a19 mutation (44 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
digestive/alimentary system
abnormal intestine physiology ( J:175382 )
• mice exhibit decreased sodium-dependent leucine uptake in sections of inverted intestine compared to in wild-type mice




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
08/02/2024
MGI 6.24 		The Jackson Laboratory